Ishiguro H, Sato S, Fujita N, Inuzuka T, Nakano R, Miyatake T
Department of Neurology, Niigata University, Japan.
Brain Res. 1991 Nov 1;563(1-2):288-92. doi: 10.1016/0006-8993(91)91548-f.
The developmental changes in localization of myelin-associated glycoprotein (MAG) isoforms in the mouse brain were demonstrated by an immunohistochemical method using antisera specific to two MAG isoforms. The antiserum to the large isoform of MAG (L-MAG) stained the myelin sheaths and the cytoplasm of oligodendroglia in the active myelinating stage in the mouse central nervous system. However, the antiserum to the small isoform of MAG (S-MAG) stained only myelin sheaths in the adult stage. These findings suggest that L-MAG plays an important role in active myelination.
