Raedler Thomas J, Schreiner Andreas, Naber Dieter, Wiedemann Klaus
Department of Psychiatry, University Medical Center Hamburg-Eppendorf, Martinistr, 52, 20246 Hamburg, Germany.
BMC Psychiatry. 2007 Jan 19;7:4. doi: 10.1186/1471-244X-7-4.
The dogma of a delayed onset of antipsychotic treatment effects has been maintained over the past decades. However, recent studies have challenged this concept. We therefore performed an analysis of the onset of antipsychotic treatment effects in a sample of acutely decompensated patients with schizophrenia.
In this observational study, 48 inpatients with acutely decompensated schizophrenia were offered antipsychotic treatment with oral risperidone. PANSS-ratings were obtained on day 0, day 1, day 3, day 7 and day 14.
Significant effects of treatment were already present on day 1 and continued throughout the study. The PANSS positive subscore and the PANSS total score improved significantly more than the PANSS negative subscore.
Our results are consistent with the growing number of studies suggesting an early onset of antipsychotic treatment effects. However, non-pharmacological effects of treatment also need to be taken into consideration.
在过去几十年里，抗精神病药物治疗效果延迟出现的教条一直存在。然而，最近的研究对这一概念提出了挑战。因此，我们对一组急性失代偿性精神分裂症患者的抗精神病药物治疗效果的起效情况进行了分析。
在这项观察性研究中，48例急性失代偿性精神分裂症住院患者接受了口服利培酮的抗精神病药物治疗。在第0天、第1天、第3天、第7天和第14天进行阳性和阴性症状量表（PANSS）评分。
治疗的显著效果在第1天就已出现，并在整个研究过程中持续存在。PANSS阳性因子分和PANSS总分的改善显著大于PANSS阴性因子分。
我们的结果与越来越多表明抗精神病药物治疗效果早期出现的研究一致。然而，治疗的非药物效果也需要考虑在内。
