小龙虾肌肉中被Cd2+阻断的新型内向整流器。

Novel inward rectifier blocked by Cd2+ in crayfish muscle.

作者信息

Araque A, Buño W

机构信息

Neurofisiología, Instituto Cajal, CSIC, Madrid, Spain.

出版信息

Brain Res. 1991 Nov 1;563(1-2):321-4. doi: 10.1016/0006-8993(91)91555-f.

DOI:10.1016/0006-8993(91)91555-f

PMID:1723924

Abstract

The characteristics of a voltage- and time-dependent inward rectifying current were examined with voltage clamp techniques in crayfish muscle. The inward current, carried by K+, was activated by hyperpolarization. Although this inward current increased with the extracellular K+ concentration [( K+]o), the voltage-dependence of the underlying conductance was independent of [K+]o. The current was unaffected by Cs+ and Ba2+, but was blocked by low concentrations of Cd2+. Therefore, this inward rectifier is different than previously described ones.

摘要

利用电压钳技术在小龙虾肌肉中研究了一种电压和时间依赖性内向整流电流的特性。由K⁺携带的内向电流通过超极化激活。尽管这种内向电流随细胞外K⁺浓度([K⁺]o)增加，但基础电导的电压依赖性与[K⁺]o无关。该电流不受Cs⁺和Ba²⁺影响，但被低浓度的Cd²⁺阻断。因此，这种内向整流器与先前描述的不同。