Ziora Katarzyna, Bubała Halina, Głowacki Jan, Sońta-Jakimczyk Danuta, Legaszewski Tomasz, Zajecki Wojciech
Katedra i Klinika Pediatrii, Nefrologii i Endokrynologii Dzieciecej Slaskiej AM w Zabrzu.
Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2006;12(4):261-7.
The modern therapy of Hodgkin's disease (HD): chemotherapy (CT) or/and radiotherapy (RT) gives a chance of a long time survival but it brings a possibility of early and late complications including thyroid gland function disorders (post-radiotherapy thyroiditis, thyroid hypofunction, Graves disease, thyroid nodules, thyroid cancer).
Evaluation of thyroid gland function in patients with total HD remission status from 6 to 16 years after the treatment.
The study included 29 patients suffering from HD (9 women, 20 men, mean age 22.8 years), treated with CT (cycles MVPP and B-DOPA) and with RT (cervical region; 18-40 Gy) in their childhood. The patients were examined by palpation, ultrasound, fine-needle aspiration biopsy. The thyroid gland on the average 6 (1st examination) and 16 years (2nd examination) after the treatment as well as thyroid hormones (TSH, fT3, fT4), thyroglobulin (Tg) and anti-thyroid antibodies in blood serum were estimated. The results were analyzed statistically; the percentage of abnormal results of estimated hormones with reference range was calculated.
There were no abnormalities in thyroid palpation examination in any patient. The mean thyroid volume in ultrasound in 2nd examination cor-responded to 66.3% of healthy individuals thyroid volume. In 8 patients thyroid nodules were found, in one thyroid papillary carcinoma was diagnosed. In one patient (3.4%) the features of subclinical thyroid hypofunction and in 17.2% the increased level of Tg in blood serum with normal thyroid hormone levels were found. In two patients (6.8%) the raised titre of a-TG and a-TPO was observed.
霍奇金淋巴瘤（HD）的现代治疗方法：化疗（CT）或/和放疗（RT）为长期生存提供了机会，但也带来了早期和晚期并发症的可能性，包括甲状腺功能障碍（放疗后甲状腺炎、甲状腺功能减退、格雷夫斯病、甲状腺结节、甲状腺癌）。
评估治疗后6至16年处于HD完全缓解状态患者的甲状腺功能。
该研究纳入了29例HD患者（9名女性，20名男性，平均年龄22.8岁），他们在儿童时期接受了CT（MVPP和B - DOPA方案）及RT（颈部区域；18 - 40 Gy）治疗。通过触诊、超声、细针穿刺活检对患者进行检查。评估治疗后平均6年（首次检查）和16年（第二次检查）时的甲状腺情况，以及血清中的甲状腺激素（促甲状腺激素、游离三碘甲状腺原氨酸、游离甲状腺素）、甲状腺球蛋白（Tg）和抗甲状腺抗体。对结果进行统计学分析；计算估计激素异常结果占参考范围的百分比。
所有患者甲状腺触诊检查均无异常。第二次检查时超声测量的平均甲状腺体积相当于健康个体甲状腺体积的66.3%。发现8例患者有甲状腺结节，1例被诊断为甲状腺乳头状癌。1例患者（3.4%）有亚临床甲状腺功能减退特征，17.2%的患者甲状腺激素水平正常但血清Tg水平升高。2例患者（6.8%）观察到抗甲状腺球蛋白抗体和抗甲状腺过氧化物酶抗体滴度升高。
