巴西儿童耐甲氧西林金黄色葡萄球菌的携带情况。
Carriage of methicillin-resistant Staphylococcus aureus in children in Brazil.
作者信息
Lamaro-Cardoso Juliana, Castanheira Mariana, de Oliveira Renato Mauricio, e Silva Simonne Almeida, Pignatari Antonio Carlos Campos, Mendes Rodrigo Elisandro, Pimenta Fabiana Cristina, Andrade Ana Lúcia Sampaio Sgambatti
机构信息
Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia-Goiás 74605-050, Brazil.
出版信息
Diagn Microbiol Infect Dis. 2007 Apr;57(4):467-70. doi: 10.1016/j.diagmicrobio.2006.10.008. Epub 2007 Jan 19.
The extent of methicillin-resistant Staphylococcus aureus (MRSA) carriage in Brazilian infants is largely unknown. We evaluated the presence of MRSA nasopharyngeal (NP) carriage in 686 children younger than 5 years with respiratory tract infection (609) and meningitis (77). S. aureus was isolated in 93 (13.5%) NP specimens of which 7 (1.02%) were identified as MRSA (oxacillin MIC, >256 microg/mL) harboring SCCmec type III. The dendrogram derived from the pulsed-field gel electrophoresis gel images showed that the MRSA strains diverged from the Brazilian endemic hospital-acquired clones from 10.4% to 21.7%. Although the MRSA strains were recovered from children within the first 6 h of their admission to hospital, the presence of SCCmec type III along with the multidrug-resistant profile of the isolates raises the hypotheses that these MRSA strains may have hospital origin and are now spreading into the pediatric community as colonizing pathogens.
巴西婴儿中耐甲氧西林金黄色葡萄球菌（MRSA）携带情况在很大程度上尚不明确。我们评估了686名5岁以下患有呼吸道感染（609例）和脑膜炎（77例）儿童的鼻咽部（NP）MRSA携带情况。在93份（13.5%）NP标本中分离出金黄色葡萄球菌，其中7份（1.02%）被鉴定为携带III型葡萄球菌盒式染色体mec（SCCmec）的MRSA（苯唑西林最低抑菌浓度，>256μg/mL）。从脉冲场凝胶电泳凝胶图像得出的树状图显示，MRSA菌株与巴西地方性医院获得性克隆株的差异为10.4%至21.7%。尽管MRSA菌株是在儿童入院后的最初6小时内分离得到的，但III型SCCmec的存在以及分离株的多重耐药特性提出了以下假设：这些MRSA菌株可能起源于医院，现在正作为定植病原体传播到儿童社区。
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