接受英夫利昔单抗治疗的患者发生隐球菌性脑膜炎。
Cryptococcal meningitis in a patient treated with infliximab.
作者信息
Muñoz Patricia, Giannella Maddalena, Valerio Maricela, Soria Teresa, Díaz Fernando, Longo Javier Lopez, Bouza Emilio
机构信息
Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, University of Madrid, 28007 Madrid, Spain.
出版信息
Diagn Microbiol Infect Dis. 2007 Apr;57(4):443-6. doi: 10.1016/j.diagmicrobio.2006.10.014. Epub 2007 Jan 19.
Infliximab, a tumor necrosis factor-alpha inhibitor, is increasingly used for the therapy of different inflammatory conditions. We report the first case of cryptococcal meningitis in a patient treated with infliximab and other immunosuppressive agents, and review a further 5 reported cryptococcal infections. All of them involved fungal pneumonia. Outcome was favorable in all cases.
英夫利昔单抗是一种肿瘤坏死因子-α抑制剂，越来越多地用于治疗各种炎症性疾病。我们报告了首例在接受英夫利昔单抗和其他免疫抑制剂治疗的患者中发生的隐球菌性脑膜炎病例，并回顾了另外5例报告的隐球菌感染病例。所有这些病例均涉及真菌性肺炎。所有病例的预后均良好。
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