群体感应ComX(RO-E-2)信息素的构效关系研究
Structure-activity relationship studies on quorum sensing ComX(RO-E-2) pheromone.
作者信息
Okada Masahiro, Yamaguchi Hisao, Sato Isao, Cho Soo Jeong, Dubnau David, Sakagami Youji
机构信息
Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan.
出版信息
Bioorg Med Chem Lett. 2007 Mar 15;17(6):1705-7. doi: 10.1016/j.bmcl.2006.12.070. Epub 2006 Dec 23.
Abstract
The ComX pheromone is a posttranslationally modified oligopeptide that stimulates natural genetic competence in Bacillus subtilis. Various ComX(RO-E-2) analogs were synthesized and their biological activities were studied to investigate structure-activity relationships. These results showed that the minimal active unit was the tripeptide, [3-5]ComX(RO-E-2), and all residues except the modified tryptophan residue were replaceable by alanine without total loss of activity.
摘要
ComX信息素是一种经翻译后修饰的寡肽，可刺激枯草芽孢杆菌的自然遗传转化能力。合成了各种ComX(RO-E-2)类似物，并研究了它们的生物活性以探究构效关系。这些结果表明，最小活性单位是三肽[3-5]ComX(RO-E-2)，除修饰的色氨酸残基外，所有残基均可被丙氨酸取代而不会完全丧失活性。
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