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脂肪型脑膜瘤

Lipomatous meningioma.

作者信息

Ohba Shigeo, Yoshida Kazunari, Akiyama Takekazu, Ikeda Eiji, Kawase Takeshi

机构信息

Department of Neurosurgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.

出版信息

J Clin Neurosci. 2007 Oct;14(10):1003-6. doi: 10.1016/j.jocn.2006.03.011. Epub 2007 Jan 19.

Abstract

We present a case of intracranial lipomatous meningioma in the parietal convexity in a 64-year-old woman. The mass showed low density on computed tomography, was hyper-intense on T1-weighted magnetic resonance images, and had decreased intensity upon imaging with fat-suppressed sequences. Gross total removal of the tumor was performed. Histopathologically, the tumor was a meningioma with mixed transitional and lipomatous patterns. Immunohistochemically, the meningothelial foci were positive for epithelial membrane antigen (EMA) and vimentin, and negative for S-100 protein. The lipomatous foci were positive for EMA, vimentin, and S-100 protein. The Ki-67 index values of the meningothelial and lipomatous foci were 1.0% and 1.8%, respectively. We review previous reports of lipomatous meningioma and discuss its clinical presentations and pathology.

摘要

我们报告一例64岁女性顶叶凸面颅内脂肪瘤型脑膜瘤病例。该肿块在计算机断层扫描上显示低密度,在T1加权磁共振图像上呈高信号,在脂肪抑制序列成像时信号强度降低。对肿瘤进行了全切除。组织病理学检查显示,肿瘤为具有混合过渡型和脂肪瘤型的脑膜瘤。免疫组织化学检查显示,脑膜上皮灶上皮膜抗原(EMA)和波形蛋白呈阳性,S-100蛋白呈阴性。脂肪瘤灶EMA、波形蛋白和S-100蛋白呈阳性。脑膜上皮灶和脂肪瘤灶的Ki-67指数值分别为1.0%和1.8%。我们回顾了既往脂肪瘤型脑膜瘤的报道,并讨论了其临床表现和病理学特征。

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