Ono Yasuhiro, Hamazaki Shuji, Ichikawa Tomotsugu, Date Isao
Department of Neurological Surgery, Okayama University Graduate School of Medicine and Dentistry.
No Shinkei Geka. 2004 Nov;32(11):1167-71.
We present a case of a 55-year-old woman with intracranial lipomatous meningioma attached to the left sphenoid ridge. A CT showed a mass lesion partially with a hypodensity area in the left fronto-temporal lobe. On MRI, the mass lesion contained a hyperintensity portion on T1 weighted images, which changed to hypointensity on fat-suppressed-T1 images. Histological examinations demonstrated a transitional meningioma containing lipomatous portions. Immunohistochemical studies showed negative reactivity for epithelial membrane antigen (EMA) and positive reactivity for vimentin and S-100 in the areas with lipomaous foci. This pattern of reactivity was different from that of lipomatous meningiomas reported previously. Further examinations are needed concerning the origin of tumor cells in lipomatous meningiomas.
我们报告一例55岁女性,患有附着于左侧蝶骨嵴的颅内脂肪瘤样脑膜瘤。CT显示左侧额颞叶有一肿块病变,部分区域呈低密度。在MRI上,肿块病变在T1加权图像上有一个高信号部分,在脂肪抑制T1图像上变为低信号。组织学检查显示为含有脂肪瘤样部分的过渡型脑膜瘤。免疫组织化学研究显示,在脂肪瘤样病灶区域,上皮膜抗原(EMA)呈阴性反应,波形蛋白和S-100呈阳性反应。这种反应模式与先前报道的脂肪瘤样脑膜瘤不同。关于脂肪瘤样脑膜瘤中肿瘤细胞的起源,还需要进一步检查。