Haxhiu M A, van Lunteren E, Cherniack N S
Department of Medicine, University Hospital of Cleveland, Case Western Reserve University, Ohio 44106.
Respir Physiol. 1991 Dec;86(3):405-14. doi: 10.1016/0034-5687(91)90110-5.
Tachykinin peptides acting on structures located on the ventral surface of the medulla can increase cholinergic outflow to the tracheal smooth muscles and augment respiratory motor output. In the experiments reported here (performed in anesthetized, paralyzed and artificially ventilated dogs), we examined the effects of tachykinin peptides substance P on secretion from submucosal glands. Changes in secretion were measured in an exposed section of tantalum-coated tracheal epithelium. Substances P was administered intracisternally or applied topically on the intermediate area of the ventral surface of medulla (VMS). Intracisternal infusion and the local medullary administration of tachykinin peptide caused a significant increase in tracheal submucosal gland secretion. Atropine given intravenously prevented the secretory changes induced by central action of tachykinins. In addition, prior application of 2% lidocaine to the medullary surface blocked the responses caused by substance P locally applied on the VMS. These findings suggest that substances P acting centrally can tracheal fluid secretion mainly via cholinergic mechanisms, and that the ventral surface of the medulla is one of the site of these action.
作用于延髓腹侧面结构的速激肽可增加气管平滑肌的胆碱能输出，并增强呼吸运动输出。在本文报道的实验中（在麻醉、麻痹并进行人工通气的狗身上进行），我们研究了速激肽P物质对黏膜下腺分泌的影响。在钽涂层气管上皮的暴露部分测量分泌变化。P物质通过脑池内给药或局部应用于延髓腹侧面中间区域（VMS）。脑池内输注和局部延髓给予速激肽可导致气管黏膜下腺分泌显著增加。静脉注射阿托品可阻止速激肽中枢作用诱导的分泌变化。此外，事先在延髓表面应用2%利多卡因可阻断局部应用于VMS的P物质引起的反应。这些发现表明，中枢作用的P物质主要通过胆碱能机制促进气管液体分泌，并且延髓腹侧面是这些作用的部位之一。
