通过药物递送凝胶对人体阴道涂层进行光学成像与分析。
Optical imaging and analysis of human vaginal coating by drug delivery gels.
作者信息
Henderson Marcus H, Couchman Grace M, Walmer David K, Peters Jennifer J, Owen Derek H, Brown Matthew A, Lavine Michael L, Katz David F
机构信息
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
出版信息
Contraception. 2007 Feb;75(2):142-51. doi: 10.1016/j.contraception.2006.08.014. Epub 2006 Oct 31.
OBJECTIVE
We used a new optical imaging technique to compare human intravaginal coating distributions of Conceptrol (Advanced Care Products, Brunswick, NJ) and Advantage (Columbia Laboratories, Aventuna, FL). These gels are surrogates for future microbicidal gels, differing in molecular structures and biophysical properties.
METHODS
For each protocol, a 3-mL gel bolus was inserted to the posterior fornix while the woman was in the supine position. She then either (1) remained supine (10 min); or (2) sat up (1 min), stood up (1 min), sat down (1 min) and returned to supine for a net elapsed time of 10 min. The imaging device is sized/shaped like a phallus, and measurements while the device was inserted provide data that simulate peri-intromission coating.
RESULTS
Coating by Advantage was more extensive and uniform than coating by Conceptrol, with smaller bare spots of uncoated epithelium. Change in posture tended to increase extent and uniformity of coating, details differing between gels.
CONCLUSIONS
Results are consistent with predictions of mechanistic coating theory, using gel rheological data as inputs.
目的
我们使用一种新的光学成像技术比较了Conceptrol（高级护理产品公司，新泽西州布伦瑞克）和Advantage（哥伦比亚实验室，佛罗里达州阿文图纳）在人体阴道内的涂层分布情况。这些凝胶是未来杀微生物凝胶的替代品，在分子结构和生物物理特性方面存在差异。
方法
对于每个方案，在女性仰卧位时将3毫升凝胶团块插入后穹窿。然后她要么（1）保持仰卧位（10分钟）；要么（2）坐起（1分钟）、站立（1分钟）、坐下（1分钟），然后再回到仰卧位，总耗时10分钟。成像设备的尺寸/形状类似阴茎，在插入设备时进行测量可提供模拟插入时涂层的数据。
结果
Advantage形成的涂层比Conceptrol更广泛、更均匀，未涂层上皮的裸露斑点更小。姿势变化往往会增加涂层的范围和均匀性，不同凝胶的具体情况有所不同。
结论
结果与将凝胶流变学数据作为输入的机械涂层理论预测一致。
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