Owen D H, Peters J J, Katz D F
Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Contraception. 2000 Dec;62(6):321-6. doi: 10.1016/s0010-7824(00)00184-0.
The rheological properties of 4 commercially available contraceptive drug delivery gels and their dilutions with a vaginal fluid simulant were measured. These properties govern the critical functions of spreading and retention of these gels over the vaginal surfaces. Measurements made on Conceptrol, KY Plus, Gynol II, and Advantage-S included stress growth, stress relaxation and residual stress, and the shear rate dependence of viscosity. All gels exhibited non-Newtonian behavior including shear thinning and viscoelasticity. Conceptrol and Gynol II had no residual stress, while both KY Plus and Advantage-S did. The gels differed in their response to dilution with vaginal fluid simulant.
对4种市售避孕药物递送凝胶及其与阴道液模拟物的稀释液的流变学特性进行了测量。这些特性决定了这些凝胶在阴道表面的铺展和滞留的关键功能。对Conceptrol、KY Plus、Gynol II和Advantage-S进行的测量包括应力增长、应力松弛和残余应力，以及粘度对剪切速率的依赖性。所有凝胶均表现出非牛顿行为，包括剪切变稀和粘弹性。Conceptrol和Gynol II没有残余应力，而KY Plus和Advantage-S都有。这些凝胶在用阴道液模拟物稀释后的反应有所不同。
