静脉注射免疫球蛋白疗法：干扰γ干扰素。

IVIG therapy: interfering with interferon-gamma.

作者信息

Clynes Raphael

机构信息

Department of Medicine and Microbiology, Columbia University, New York, NY 10032, USA.

出版信息

Immunity. 2007 Jan;26(1):4-6. doi: 10.1016/j.immuni.2007.01.006.

DOI:10.1016/j.immuni.2007.01.006

PMID:17241954

Abstract

The immunosuppressive mechanism of action of intravenous immune globulin (IVIG) has remained enigmatic despite the many years of clinical experience in the treatment of autoimmunity. In this issue of Immunity, Park-Min et al. demonstrate that IVIG engagement of Fcgamma RIII receptor on monocytes inhibits the cellular response to interferon-gamma.

摘要

尽管静脉注射免疫球蛋白（IVIG）在自身免疫性疾病治疗方面已有多年临床经验，但其免疫抑制作用机制仍不明确。在本期《免疫》杂志中，朴敏等人证明，IVIG与单核细胞上的FcγRIII受体结合会抑制细胞对干扰素-γ的反应。