抗体和补体介导的同种异体移植物排斥反应的机制。
Mechanisms involved in antibody- and complement-mediated allograft rejection.
机构信息
Department of Pathology, The Johns Hopkins University School of Medicine, Ross Bldg. 664B, Baltimore, MD 21205, USA.
出版信息
Immunol Res. 2010 Jul;47(1-3):25-44. doi: 10.1007/s12026-009-8136-3.
Abstract
Antibody-mediated rejection has become critical clinically because this form of rejection is usually unresponsive to conventional anti-rejection therapy, and therefore, it has been recognized as a major cause of allograft loss. Our group developed experimental animal models of vascularized organ transplantation to study pathogenesis of antibody- and complement-mediated endothelial cell injury leading to graft rejection. In this review, we discuss mechanisms of antibody-mediated graft rejection resulting from activation of complement by C1q- and MBL (mannose-binding lectin)-dependent pathways and interactions with a variety of effector cells, including macrophages and monocytes through Fcgamma receptors and complement receptors.
摘要
抗体介导的排斥反应已成为临床上的一个关键问题，因为这种排斥反应通常对常规的抗排斥治疗无反应，因此，它已被认为是同种异体移植物丢失的主要原因。我们小组建立了血管化器官移植的实验动物模型，以研究导致移植物排斥的抗体和补体介导的内皮细胞损伤的发病机制。在这篇综述中，我们讨论了补体通过 C1q 和 MBL（甘露聚糖结合凝集素）依赖性途径的激活以及与各种效应细胞（包括巨噬细胞和单核细胞）通过 Fcγ 受体和补体受体的相互作用导致抗体介导的移植物排斥的机制。
相似文献
1
Mechanisms involved in antibody- and complement-mediated allograft rejection.
Immunol Res. 2010 Jul;47(1-3):25-44. doi: 10.1007/s12026-009-8136-3.
2
Mechanisms of complement activation, C4d deposition, and their contribution to the pathogenesis of antibody-mediated rejection.
Transplant Rev (Orlando). 2009 Jul;23(3):139-50. doi: 10.1016/j.trre.2009.02.005. Epub 2009 Apr 10.
3
[The role of endothelial cells in allograft rejection].
Pathologe. 2008 Nov;29 Suppl 2:141-4. doi: 10.1007/s00292-008-1077-0.
4
Antibody-mediated organ-allograft rejection.
Nat Rev Immunol. 2005 Oct;5(10):807-17. doi: 10.1038/nri1702.
5
Complement activation by anti-endothelial cell antibodies in MHC-mismatched and MHC-matched heart allograft rejection: anti-MHC-, but not anti non-MHC alloantibodies are effective in complement activation.
Transpl Int. 2000;13(5):363-71. doi: 10.1007/s001470050715.
6
Relative Frequencies of Alloantigen-Specific Helper CD4 T Cells and B Cells Determine Mode of Antibody-Mediated Allograft Rejection.
Front Immunol. 2019 Jan 22;9:3039. doi: 10.3389/fimmu.2018.03039. eCollection 2018.
7
Passive transfer of alloantibodies restores acute cardiac rejection in IgKO mice.
Transplantation. 2001 Mar 27;71(6):727-36. doi: 10.1097/00007890-200103270-00007.
8
Detection of alloantibody-mediated complement activation: A diagnostic advance in monitoring kidney transplant rejection?
Clin Biochem. 2016 Mar;49(4-5):394-403. doi: 10.1016/j.clinbiochem.2015.05.024. Epub 2015 Jun 26.
9
Donor deficiency of decay-accelerating factor accelerates murine T cell-mediated cardiac allograft rejection.
J Immunol. 2008 Oct 1;181(7):4580-9. doi: 10.4049/jimmunol.181.7.4580.
10
Donor-Specific Antibodies in Kidney Transplant Recipients.
Clin J Am Soc Nephrol. 2018 Jan 6;13(1):182-192. doi: 10.2215/CJN.00700117. Epub 2017 Apr 26.
引用本文的文献
1
Complement in Antibody-Mediated Rejection of the Kidney Graft: From Pathophysiology to Clinical Practice.
J Clin Med. 2025 Apr 18;14(8):2810. doi: 10.3390/jcm14082810.
2
Dynamic Neutrophil Subsets and Function in Lung Transplant Recipients: Insights from a One-Year Longitudinal Pilot Study.
J Clin Med. 2025 Apr 13;14(8):2660. doi: 10.3390/jcm14082660.
3
Ablation of FAS confers allogeneic CD3 CAR T cells with resistance to rejection by T cells and natural killer cells.
Nat Biomed Eng. 2024 Dec;8(12):1651-1664. doi: 10.1038/s41551-024-01282-8. Epub 2024 Nov 18.
4
The Effects of IL-23/IL-18-Polarized Neutrophils on Renal Ischemia-Reperfusion Injury and Allogeneic-Skin-Graft Rejection in Mice.
Biomedicines. 2023 Nov 26;11(12):3148. doi: 10.3390/biomedicines11123148.
5
TLR7 Activation Accelerates Cardiovascular Pathology in a Mouse Model of Lupus.
Front Immunol. 2022 Jul 4;13:914468. doi: 10.3389/fimmu.2022.914468. eCollection 2022.
6
Molecular Assessment of C4d-Positive Renal Transplant Biopsies Without Evidence of Rejection.
Kidney Int Rep. 2018 Sep 18;4(1):148-158. doi: 10.1016/j.ekir.2018.09.005. eCollection 2019 Jan.
7
Non-canonical activity of the podosomal formin FMNL1γ supports immune cell migration.
J Cell Sci. 2017 May 15;130(10):1730-1739. doi: 10.1242/jcs.195099. Epub 2017 Mar 27.
8
The Effect of Tacrolimus and Mycophenolic Acid on CD14+ Monocyte Activation and Function.
PLoS One. 2017 Jan 25;12(1):e0170806. doi: 10.1371/journal.pone.0170806. eCollection 2017.
9
The Impact of HLA Class I-Specific Killer Cell Immunoglobulin-Like Receptors on Antibody-Dependent Natural Killer Cell-Mediated Cytotoxicity and Organ Allograft Rejection.
Front Immunol. 2016 Dec 19;7:585. doi: 10.3389/fimmu.2016.00585. eCollection 2016.
10
The Role of Neutrophils in Transplanted Organs.
Am J Transplant. 2017 Feb;17(2):328-335. doi: 10.1111/ajt.13940. Epub 2016 Jul 25.
本文引用的文献
1
Platelets influence vascularized organ transplants from start to finish.
Am J Transplant. 2009 Jan;9(1):14-22. doi: 10.1111/j.1600-6143.2008.02473.x. Epub 2008 Nov 27.
2
Accommodation in organ transplantation.
Curr Opin Organ Transplant. 2008 Apr;13(2):165-70. doi: 10.1097/MOT.0b013e3282f6391e.
3
In vivo platelet-endothelial cell interactions in response to major histocompatibility complex alloantibody.
Circ Res. 2008 Apr 11;102(7):777-85. doi: 10.1161/CIRCRESAHA.107.170332. Epub 2008 Feb 22.
4
Anti-MHC class I antibody activation of proliferation and survival signaling in murine cardiac allografts.
J Immunol. 2008 Feb 15;180(4):2214-24. doi: 10.4049/jimmunol.180.4.2214.
5
Fcgamma receptors as regulators of immune responses.
Nat Rev Immunol. 2008 Jan;8(1):34-47. doi: 10.1038/nri2206.
6
The involvement of FcR mechanisms in antibody-mediated rejection.
Transplantation. 2007 Nov 27;84(10):1324-34. doi: 10.1097/01.tp.0000287457.54761.53.
7
Protective mechanisms of IVIG.
Curr Opin Immunol. 2007 Dec;19(6):646-51. doi: 10.1016/j.coi.2007.09.004. Epub 2007 Nov 26.
8
Fc-receptors as regulators of immunity.
Adv Immunol. 2007;96:179-204. doi: 10.1016/S0065-2776(07)96005-8.
9
Platelets an inflammatory force in transplantation.
Am J Transplant. 2007 Nov;7(11):2447-54. doi: 10.1111/j.1600-6143.2007.01958.x.
10
Synergistic deposition of C4d by complement-activating and non-activating antibodies in cardiac transplants.
Am J Transplant. 2007 Nov;7(11):2605-14. doi: 10.1111/j.1600-6143.2007.01971.x. Epub 2007 Sep 14.
Zotero 插件