对比谐波超声引导下射频消融治疗与B超在肝细胞癌中的应用：前瞻性随机对照试验。

Contrast harmonic sonography-guided radiofrequency ablation therapy versus B-mode sonography in hepatocellular carcinoma: prospective randomized controlled trial.

作者信息

Minami Yasunori, Kudo Masatoshi, Chung Hobyung, Kawasaki Toshihiko, Yagyu Yukinobu, Shimono Taro, Shiozaki Hitoshi

机构信息

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayma, Osaka 589-8511, Japan.

出版信息

AJR Am J Roentgenol. 2007 Feb;188(2):489-94. doi: 10.2214/AJR.05.1286.

DOI:10.2214/AJR.05.1286

PMID:17242259

Abstract

OBJECTIVE

The purpose of this study was to evaluate the effectiveness of contrast harmonic sonographic guidance in radiofrequency ablation of locally progressive hepatocellular carcinoma poorly depicted with B-mode sonography.

SUBJECTS AND METHODS

A series of 40 patients with hepatocellular carcinoma with local tumor progression poorly depicted with B-mode sonography were randomly treated with radiofrequency ablation guided by either contrast harmonic sonography (n = 20) or conventional B-mode sonography (n = 20). Unpaired Student's t tests were performed to compare numbers of treatment sessions.

RESULTS

Treatment analysis showed that the complete ablation rate after a single treatment session was significantly higher in the contrast harmonic sonography group than in the B-mode sonography group (94.7% vs 65.0%; p = 0.043) and that the number of treatment sessions was significantly lower in the contrast harmonic sonography group (mean, 1.1 +/- 0.2 vs 1.4 +/- 0.6; p =0.037).

CONCLUSION

Contrast harmonic sonography-guided radiofrequency ablation is an efficient technique for guiding further ablation of local tumor progression not clearly demarcated with B-mode sonography.

摘要