Farid Reza, Ghasemi Ramin, Baradaran-Rahimi Mahmood, Jabbari Farahzad, Ghaffari Javad, Rafatpanah Hooshang
Immunology Research Centre, Buali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Allergy Asthma Immunol. 2006 Mar;5(1):29-31.
Allergen immunotherapy involves the administration of gradually increasing quantities of specific allergens to patients with IgE-mediated conditions until a dose is reached that is effective in reducing disease severity from natural exposure. In the present study we evaluated a period of six years immunotherapy allergic rhinitis and allergic asthma patients with positive skin prick test of common aeroallergen. The immunotherapy was performed on 156 patients. One hundred twenty of the cases were allergic rhinitis (80%), 29 cases had allergic asthma and 7 cases were mixed (4.5%). 70% in allergic rhinitis group, 75% in allergic asthma group and 42.8% in mixed group completely improved. Immunotherapy, an older therapeutic method, has now been updated, and with appropriate indications, precautions and methods, has been clearly shown to be effective in the treatment of allergic rhinitis and in some cases of asthma and insect hypersensitivity.
变应原免疫疗法是指给患有IgE介导疾病的患者逐渐增加特定变应原的剂量,直至达到有效减轻自然暴露所致疾病严重程度的剂量。在本研究中,我们评估了对常见气传变应原皮肤点刺试验呈阳性的变应性鼻炎和变应性哮喘患者进行为期六年的免疫疗法。对156例患者实施了免疫疗法。其中120例为变应性鼻炎(80%),29例有变应性哮喘,7例为混合型(4.5%)。变应性鼻炎组70%、变应性哮喘组75%以及混合型组42.8%的患者完全康复。免疫疗法作为一种较古老的治疗方法,现已得到更新,并且在有适当适应证、预防措施和方法的情况下,已明确显示对变应性鼻炎以及某些哮喘和昆虫超敏反应病例有效。