骨转换标志物与镰状细胞贫血年轻患者的生长发育相关。
Markers of bone turnover are associated with growth and development in young subjects with sickle cell anemia.
作者信息
Fung Ellen B, Kawchak Deborah A, Zemel Babette S, Rovner Alisha J, Ohene-Frempong Kwaku, Stallings Virginia A
机构信息
Department of Hematology, The Children's Hospital & Research Center, Oakland, California, USA.
出版信息
Pediatr Blood Cancer. 2008 Mar;50(3):620-3. doi: 10.1002/pbc.21147.
Abstract
Children with sickle cell anemia (SCA) have low bone mass though bone turnover has not been well described. In this study, growth and pubertal development were assessed twice, 1 year apart, in 80 young subjects with type-SS SCA, while whole body bone mineral content (BMC) and density where measured in a subset (n = 46). Markers of bone turnover were measured at the second visit. Bone formation (alkaline phosphatase) was elevated, whereas bone resorption (deoxypyridinoline) was decreased compared to published data in healthy children. Markers of bone turnover correlated with growth velocity and pubertal development but not with changes in bone mass.
摘要
患有镰状细胞贫血（SCA）的儿童骨量较低，尽管骨转换情况尚未得到充分描述。在本研究中，对80名患有SS型SCA的年轻受试者进行了两次评估，每次评估间隔1年，以评估其生长和青春期发育情况，同时对其中一部分受试者（n = 46）测量了全身骨矿物质含量（BMC）和骨密度。在第二次访视时测量了骨转换标志物。与健康儿童的已发表数据相比，骨形成（碱性磷酸酶）升高，而骨吸收（脱氧吡啶啉）降低。骨转换标志物与生长速度和青春期发育相关，但与骨量变化无关。
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