Romero L, Muñoz C, López A, Vilches J
Departamento de Biología Celular y Anatomía Patológica, Facultad de Medicina de Cádiz.
Actas Urol Esp. 1991 Nov-Dec;15(6):503-9.
The relationship between prolactin in NH and prostate carcinoma has several aspects: under normal conditions, prolactin enhances androgens output, increasing the Leydig cell susceptibility to LH. At the prostate level, it increases testosterone binding to the prostate epithelium and stimulates the conversion of testosterone to dihydrotestosterone. On its own, it decreases prostatic protein degradation and increases the DNA synthesis index. With regard to Nodular Hyperplasia, once its hormone dependency is rated, it also appears to be stimulated by high levels of prolactin. The NH cell cultures with human prostate increase their growth, cell division, as well as the DNA synthesis. The aspects of the prolactin-prostate carcinoma interaction involve considering this hormone as a possible carcinogenic agent, emphasizing the existence of high plasma levels of this hormone in individuals with prostate carcinoma, where any androgen excess is considered a major factor at the genesis of this tumour, and prolactin increases indirectly its testicular synthesis. Also, prolactin itself stimulates the growth and development of carcinomatous human cell lines, increasing its effect in the presence of testosterone. For this reason, controlling this hormone levels becomes an element to have into consideration in the treatment and follow-up of these patients; also, the reevaluation of any drug therapy that, besides the initial goal pursued, does not maintain baseline prolactin levels. The association of anti-prolactin drugs has to be understood as a co-adjuvant therapy when there is androgenic deprivation, never as a single treatment.
非那雄胺（NH）中的催乳素与前列腺癌之间的关系有几个方面：在正常情况下，催乳素可提高雄激素的分泌，增加睾丸间质细胞对促黄体生成素（LH）的敏感性。在前列腺水平，它可增加睾酮与前列腺上皮的结合，并刺激睾酮向双氢睾酮的转化。就其本身而言，它可减少前列腺蛋白降解并增加DNA合成指数。关于结节性增生，一旦确定其激素依赖性，似乎也受到高水平催乳素的刺激。用人前列腺进行的NH细胞培养可增加其生长、细胞分裂以及DNA合成。催乳素与前列腺癌相互作用的方面包括将这种激素视为一种可能的致癌剂，强调前列腺癌患者血浆中这种激素水平较高的情况，其中任何雄激素过量都被认为是该肿瘤发生的主要因素，而催乳素会间接增加其睾丸合成。此外，催乳素本身可刺激人癌细胞系的生长和发育，在有睾酮存在时其作用会增强。因此，控制这种激素水平成为这些患者治疗和随访中需要考虑的一个因素；同样，对任何除了最初追求的目标外不能维持基线催乳素水平的药物治疗进行重新评估。当存在雄激素剥夺时，抗催乳素药物的联合应用必须被理解为一种辅助治疗，绝不能作为单一治疗。
