Nutrition, body weight and deterioration of familial combined hyperlipidemia.

Lipid and apolipoprotein serum levels as a consequence of excessive nutrition in the overweight individuals with familial combined hyperlipidemia (FCHL) in comparison with the obese ones are studied only sporadically. In this study, the effect of overweight and obesity in subjects with FCHL on serum lipids and apolipoproteins was investigated. The participants were 36 overweight and 10 obese men. 17 normolipidemic healthy men served as the control group. The mean age of all subjects included was 49+/-9 years. Lipid and apolipoprotein serum levels were determined by standard methods. The increased body weight in overweight men with FCHL correlates with increased cholesterol and triacylglycerol serum levels (p<0.001), atherogenous ratio values, apolipoprotein serum levels--apo C-III, apo C-II and apo B100oo (p<0.001) as well as decreased HDL cholesterol serum levels (p<0.05). Lipid metabolism in men with FCHL is deteriorated by a high energy intake and its low output. The overweight and not only obesity, in association with FCHL, is an important risk factor for premature development of ischemic events.