人类毛小皮的一种超高硫角蛋白基因位于11q13，并且与11p15处的序列交叉杂交。

An ultrahigh-sulphur keratin gene of the human hair cuticle is located at 11q13 and cross-hybridizes with sequences at 11p15.

作者信息

MacKinnon P J, Powell B C, Rogers G E, Baker E G, MacKinnon R N, Hyland V J, Callen D F, Sutherland G R

机构信息

Department of Biochemistry, University of Adelaide, Australia.

出版信息

Mamm Genome. 1991;1(1):53-6. doi: 10.1007/BF00350846.

DOI:10.1007/BF00350846

PMID:1724400

Abstract

A human hair cuticle ultrahigh-sulphur keratin Q (UHSK) gene (KRN1) has been mapped by Southern analysis of a somatic cell hybrid panel and by in situ hybridization. A probe containing the coding region of this gene mapped to 11pter- greater than 11q21 using the hybrid cell panel and on in situ hybridization mapped to two regions on chromosome 11: the distal part of 11p15, most likely 11p15.5, and the distal part of 11q13, most likely 11q13.5. A probe from the 3' noncoding region of KRN1 mapped to 11q13.5 indicating that this was the map location of the cloned gene. The sequence of 11p15.5 is termed KRN1-like (KRN1L). The results reveal that the cuticle UHSK gene family is clustered in the human genome.

摘要

通过对体细胞杂种板进行Southern分析和原位杂交，已对人毛发角蛋白超高硫角蛋白Q（UHSK）基因（KRN1）进行了定位。使用杂种细胞板，包含该基因编码区的探针定位于11pter-大于11q21，原位杂交显示定位于11号染色体上的两个区域：11p15的远端部分，最可能是11p15.5，以及11q13的远端部分，最可能是11q13.5。来自KRN1 3'非编码区的探针定位于11q13.5，表明这是克隆基因的图谱位置。11p15.5的序列被称为KRN1样（KRN1L）。结果表明，表皮UHSK基因家族在人类基因组中是成簇分布的。