Hyland V J, Grist S, Callen D F, Sutherland G R
Department of Histopathology, Adelaide Children's Hospital, Australia.
Am J Hum Genet. 1988 Feb;42(2):373-9.
Anonymous DNA probes specific for human chromosome 16 were isolated from a flow-purified human chromosome 16 library. The library was constructed at the Lawrence Livermore National Laboratory. Twenty-nine clones containing a unique or low-copy DNA insert were isolated. Of these, six were assigned to chromosome 16 and regionally mapped and 12 were shown not to map to chromosome 16. One clone mapped to 16pter----16p13.1, one clone to 16p11.1----16q13, one clone to 16q13----16q22.1, and three clones to 16q22.1----16q24. An additional clone from the same library was mapped to 16q13----16q22.1.
从一个经流式纯化的人类16号染色体文库中分离出了对人类16号染色体特异的匿名DNA探针。该文库由劳伦斯利弗莫尔国家实验室构建。分离出了29个含有独特或低拷贝DNA插入片段的克隆。其中,6个被定位到16号染色体并进行了区域定位,12个显示不定位到16号染色体。一个克隆定位到16pter----16p13.1,一个克隆定位到16p11.1----16q13,一个克隆定位到16q13----16q22.1,三个克隆定位到16q22.1----16q24。来自同一文库的另一个克隆定位到16q13----16q22.1。