Gambichler T, Boms S, Hochdorfer B, Altmeyer P, Kreuter A
Department of Dermatology, Ruhr-University Bochum, Gudrunstr. 56, D-44791 Bochum, Germany.
Clin Exp Dermatol. 2007 Mar;32(2):155-8. doi: 10.1111/j.1365-2230.2006.02329.x. Epub 2007 Jan 18.
Amicrobial pustulosis of the folds (APF), is a rare pustular eruption, predominantly involving the cutaneous folds, the external auditory canals and the scalp, occurring in patients who exhibit a wide spectrum of autoimmune abnormalities. There is a lack of data on the immunohistology of APF. We report a new case of APF associated with features of systemic lupus erythematosus (LE). Extensive immunohistological examinations of lesional and nonlesional skin were performed. The results of our immunohistological studies indicate that immunostaining with p53, Bcl-2, and CD8 antigens could be useful in differentiating APF from closely related inflammatory conditions such as psoriasis and cutaneous LE. However, studies on a larger sample size including controls are needed to substantiate our findings.
褶皱部无菌性脓疱病（APF）是一种罕见的脓疱性皮疹，主要累及皮肤褶皱处、外耳道和头皮，见于有多种自身免疫异常的患者。目前关于APF免疫组织学方面的数据较少。我们报告1例伴有系统性红斑狼疮（LE）特征的APF新病例。对皮损及非皮损皮肤进行了广泛的免疫组织学检查。我们免疫组织学研究结果表明，p53、Bcl-2和CD8抗原免疫染色有助于鉴别APF与银屑病和皮肤型LE等密切相关的炎症性疾病。然而，需要对包括对照在内的更大样本量进行研究以证实我们的发现。
