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在使用从右心室到肺动脉的分流装置进行诺伍德手术姑息治疗后,心室切开术是否具有有害影响?

Does a ventriculotomy have deleterious effects following palliation in the Norwood procedure using a shunt placed from the right ventricle to the pulmonary arteries?

作者信息

Graham Eric M, Atz Andrew M, Bradley Scott M, Scheurer Mark A, Bandisode Varsha M, Laudito Antonio, Shirali Girish S

机构信息

Division of Pediatric Cardiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

出版信息

Cardiol Young. 2007 Apr;17(2):145-50. doi: 10.1017/S1047951107000133. Epub 2007 Jan 23.

Abstract

INTRODUCTION

A recent modification to the Norwood procedure involving a shunt placed directly from the right ventricle to the pulmonary arteries may improve postoperative haemodynamics. Concerns remain, however, about the potential problems produced by the required ventriculotomy.

METHODS

We compared 76 patients with hypoplastic left heart syndrome who underwent the Norwood procedure, 35 receiving a modified Blalock-Taussig shunt and the remaining 41 a shunt placed directly from the right ventricle to the pulmonary arteries. We reviewed their subsequent progress through the second stage of palliation. A single observer graded right ventricular function, and the severity of tricuspid regurgitation, based on blinded review of the most recent echocardiograms prior to the second stage of palliation.

RESULTS

At the time of catheterization prior to the second stage, patients with a shunt placed from the right ventricle to the pulmonary arteries, rather than a modified Blalock-Taussig shunt, had higher arterial diastolic blood pressure, at 44 versus 40 millimetres of mercury, p equal to 0.02, lower ventricular end diastolic pressures, at 8 versus 11 millimetres of mercury, p equal to 0.0002, and larger pulmonary arteries as judged using the Nakata index, at 270 versus 188 millimetres squared per metres squared, p equal to 0.009. There was no difference in qualitative ventricular systolic function or tricuspid regurgitation between groups. No differences were found between groups during the hospitalization following the second stage of palliation. A trend towards improved survival to the second stage was seen following the construction of a shunt from the right ventricle to the pulmonary arteries.

CONCLUSIONS

Construction of a shunt from the right ventricle to the pulmonary arteries is associated with lower right ventricular end diastolic pressures, larger pulmonary arterial size, and higher systemic arterial diastolic pressures. No apparent deleterious effects of the right ventriculotomy were observed in terms of qualitative ventricular systolic function or tricuspid regurgitation.

摘要

引言

诺伍德手术最近的一项改进是直接从右心室到肺动脉置入分流管,这可能会改善术后血流动力学。然而,对于所需的心室切开术所产生的潜在问题仍存在担忧。

方法

我们比较了76例接受诺伍德手术的左心发育不全综合征患者,其中35例接受改良布莱洛克-陶西格分流术,其余41例直接从右心室到肺动脉置入分流管。我们回顾了他们在二期姑息治疗阶段的后续进展。一名观察者根据对二期姑息治疗前最新超声心动图的盲法评估,对右心室功能和三尖瓣反流的严重程度进行分级。

结果

在二期姑息治疗前进行导管插入术时,直接从右心室到肺动脉置入分流管的患者,而非改良布莱洛克-陶西格分流术的患者,动脉舒张压更高,分别为44毫米汞柱和40毫米汞柱,p = 0.02;心室舒张末期压力更低,分别为8毫米汞柱和11毫米汞柱,p = 0.0002;使用中田指数判断,肺动脉更大,分别为每平方米270平方毫米和188平方毫米,p = 0.009。两组间心室收缩功能或三尖瓣反流的定性评估没有差异。在二期姑息治疗后的住院期间,两组间未发现差异。在构建从右心室到肺动脉的分流管后,观察到二期姑息治疗生存率有提高的趋势。

结论

构建从右心室到肺动脉的分流管与更低的右心室舒张末期压力、更大的肺动脉尺寸以及更高的体循环动脉舒张压相关。在心室收缩功能定性评估或三尖瓣反流方面,未观察到右心室切开术有明显的有害影响。

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