mRNA 降解的方方面面

The highways and byways of mRNA decay.

作者信息

Garneau Nicole L, Wilusz Jeffrey, Wilusz Carol J

机构信息

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA.

出版信息

Nat Rev Mol Cell Biol. 2007 Feb;8(2):113-26. doi: 10.1038/nrm2104.

DOI:10.1038/nrm2104

PMID:17245413

Abstract

When considering the control of gene expression, the focus has traditionally been on transcriptional regulation. Recently, however, the large contribution made by mRNA decay has become difficult to ignore. Large-scale analyses indicate that as many as half of all changes in the amounts of mRNA in some responses can be attributed to altered rates of decay. In this article, we discuss some of the mechanisms that are used by the cell to mediate and regulate this intriguing process.

摘要

在考虑基因表达的调控时，传统上关注的焦点一直是转录调控。然而，最近mRNA降解所起的巨大作用已变得不容忽视。大规模分析表明，在某些反应中，mRNA量的所有变化中多达一半可归因于降解速率的改变。在本文中，我们讨论了细胞用于介导和调控这一有趣过程的一些机制。