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盐酸海他明对青蛙离体单收缩肌纤维收缩特性的作用。

Action of heptaminol hydrochloride on contractile properties in frog isolated twitch muscle fibre.

作者信息

Allard B, Jacquemond V, Lemtiri-Chlieh F, Pourrias B, Rougier O

机构信息

Laboratoire de Physiologie des Eléments Excitables (CNRS UA 180), Université Claude Bernard Lyon I, Villeurbanne, France.

出版信息

Br J Pharmacol. 1991 Nov;104(3):714-8. doi: 10.1111/j.1476-5381.1991.tb12493.x.

DOI:10.1111/j.1476-5381.1991.tb12493.x
PMID:1724630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1908234/
Abstract
  1. Heptaminol stopped or delayed the progressive decline in tension which characterizes the phenomenon of fatigue in frog isolated twitch muscle fibre. 2. Heptaminol had no action on the sodium, potassium and calcium voltage-dependent ionic conductances. 3. The hypothesis of an action via an internal alkalinization was tested by comparison with the action of NH4Cl. Both substances increased the tension. 4. The action of heptaminol was suppressed in sodium-free (TRIS) solution or in the presence of amiloride while the action of NH4Cl was always observed. 5. These results could be explained by a stimulation of the Na/H antiport by heptaminol.
摘要
  1. 庚胺醇阻止或延缓了张力的逐渐下降，这种张力下降是青蛙离体抽搐肌纤维疲劳现象的特征。2. 庚胺醇对钠、钾和钙电压依赖性离子电导没有作用。3. 通过与氯化铵的作用进行比较，检验了通过内部碱化起作用的假说。两种物质都增加了张力。4. 在无钠（TRIS）溶液中或存在氨氯吡咪时，庚胺醇的作用受到抑制，而氯化铵的作用始终可以观察到。5. 这些结果可以通过庚胺醇对钠/氢反向转运体的刺激来解释。
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff33/1908234/e15fb6febf0c/brjpharm00231-0151-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff33/1908234/ca4011c24199/brjpharm00231-0149-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff33/1908234/bc31449f95eb/brjpharm00231-0150-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff33/1908234/129c400422c0/brjpharm00231-0151-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff33/1908234/e15fb6febf0c/brjpharm00231-0151-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff33/1908234/ca4011c24199/brjpharm00231-0149-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff33/1908234/bc31449f95eb/brjpharm00231-0150-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff33/1908234/129c400422c0/brjpharm00231-0151-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff33/1908234/e15fb6febf0c/brjpharm00231-0151-b.jpg

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Action of heptaminol hydrochloride on contractile properties in frog isolated twitch muscle fibre.盐酸海他明对青蛙离体单收缩肌纤维收缩特性的作用。
Br J Pharmacol. 1991 Nov;104(3):714-8. doi: 10.1111/j.1476-5381.1991.tb12493.x.
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Characterization of tension decline in different types of fatigue-resistant skeletal muscle fibres of the frog. Low extracellular calcium effects.青蛙不同类型抗疲劳骨骼肌纤维中张力下降的特征。细胞外钙浓度低的影响。
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Effects of physostigmine on the voltage dependent ionic conductances of skeletal muscle fibres.毒扁豆碱对骨骼肌纤维电压依赖性离子电导的影响。
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Effects of physostigmine on the excitation-contraction coupling of skeletal muscle fibres.毒扁豆碱对骨骼肌纤维兴奋-收缩偶联的影响。
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[Heptaminol chlorhydrate: new data].盐酸海他明醇：新数据
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[Heptaminol hydrochloride as an epithelium transporter].盐酸海他明醇作为一种上皮转运体
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本文引用的文献

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[Actions of heptaminol HCl on the cardiovascular and curarizing effects of D-tubocurarine].[盐酸海他明对筒箭毒碱心血管及箭毒样作用的影响]
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[Heptaminol and nervous fatigue].[海他明醇与神经疲劳]
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C R Seances Soc Biol Fil. 1953 May;147(9-10):774-9.
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Calcium-dependent electrical activity and contraction of voltage-clamped frog single muscle fibres.电压钳制的青蛙单根肌纤维的钙依赖性电活动和收缩
J Physiol. 1980 Oct;307:9-22. doi: 10.1113/jphysiol.1980.sp013420.
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Existence of a sodium-induced calcium release mechanism of frog skeletal muscle fibres.蛙骨骼肌纤维钠诱导钙释放机制的存在。
J Physiol. 1982 Dec;333:463-80. doi: 10.1113/jphysiol.1982.sp014464.
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Intracellular pH.细胞内pH值
Physiol Rev. 1981 Apr;61(2):296-434. doi: 10.1152/physrev.1981.61.2.296.
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Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts.人成纤维细胞中生长因子作用下的钠/氢交换与细胞质酸碱度
Nature. 1983;304(5927):645-8. doi: 10.1038/304645a0.
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The effects of some inhalation anaesthetics on the sodium current of the squid giant axon.某些吸入麻醉剂对乌贼巨大轴突钠电流的影响。
J Physiol. 1983 Aug;341:429-39. doi: 10.1113/jphysiol.1983.sp014814.
10
Voltage dependent charge movement of skeletal muscle: a possible step in excitation-contraction coupling.骨骼肌的电压依赖性电荷移动：兴奋-收缩偶联中的一个可能步骤。
Nature. 1973 Mar 23;242(5395):244-6. doi: 10.1038/242244a0.