Macro- and microscopic examinations of the viscera and hemopoietic organs of 405 dead patients who had suffered from various forms of acute leukemia were performed as well as microscopic investigations of 560 punch biopsies obtained from 372 patients at different stages of the disease. Pathomorphological findings on acute leukemias are presented, changes in the disease in the course of cytostatic antileukemia treatment are observed. Morphological signs of therapeutic pathomorphosis of acute leukemia involve: reduction or eradication of leukemic growths in the viscera and hemopoietic organs; hemopoietic hypo- and aplasia; dystrophic and necrobiotic alterations in the organs; topographic changes of leukemic proliferates (extramedullary localization of the process); augmentation of infectious and inflammatory complications; other causes of death.
对405例死于各种急性白血病的患者的内脏和造血器官进行了大体和显微镜检查，并对372例处于疾病不同阶段的患者的560份穿刺活检组织进行了显微镜检查。文中呈现了急性白血病的病理形态学发现，观察了细胞毒性抗白血病治疗过程中疾病的变化。急性白血病治疗性病理形态改变的形态学特征包括：内脏和造血器官中白血病细胞增生的减少或消除；造血功能减退和再生障碍；器官的营养不良性和坏死性改变；白血病细胞增生的部位变化（病变的髓外定位）；感染性和炎症性并发症增加；其他死亡原因。
