Nizze H, Brockmöller S, Bast R, Schmitt E
Institut für Pathologie, Universität Rostock.
Verh Dtsch Ges Pathol. 1991;75:218-23.
The infectious consequences of immune deficiency after kidney transplantation are reflected in the spectrum of the causes of deaths in a renal transplant population. From 1976 to 1991, 650 kidney transplantations were performed in Rostock. An autopsy was made in 92 of the altogether 106 deaths; 45 (49%) showed infectious and 47 (51%) non-infectious causes of death. A significant decrease of bacterial causes of death was found in the transplant group from 1985 to 1991 (3/25 = 12%) in comparison to the group from 1976 to 1985 (30/67 = 45%). The important increase of patient survival is attributed to the progress of transplantation management in general as well as to the striking decrease of lethal bacterial infections due to increasing ciclosporin application in renal transplantation.
肾移植后免疫缺陷的感染后果反映在肾移植人群的死亡原因谱中。1976年至1991年期间，罗斯托克共进行了650例肾移植手术。在总共106例死亡病例中，有92例进行了尸检；45例（49%）显示为感染性死亡原因，47例（51%）为非感染性死亡原因。与1976年至1985年组（30/67 = 45%）相比，1985年至1991年移植组细菌导致的死亡显著减少（3/25 = 12%）。患者生存率的显著提高归因于总体移植管理的进步，以及肾移植中环孢素应用增加导致致命细菌感染显著减少。
