Thomas Biju B, Aramant Robert B, Sadda SriniVas R, Seiler Magdalene J
Dept. Ophthalmology, Doheny Retina Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Adv Exp Med Biol. 2006;572:367-76.
Retinal transplantation is one among the various treatment strategies aimed to prevent and restore visual loss. Sheets of fetal retina with or without retinal pigment epithelium (RPE) are transplanted into the subretinal space. Retinal transplants have been shown to substantially improve visual responses in rat retinal degeneration models following retinal transplantation, based on behavior and electrophysiology. The transplantation effects may be influenced by several factors such as the age of the recipient at transplantation and the type of species used. Modified functional evaluation techniques permit better understanding of the physiological mechanisms underlying visual improvement in animal models.
视网膜移植是旨在预防和恢复视力丧失的多种治疗策略之一。将带有或不带有视网膜色素上皮（RPE）的胎儿视网膜片移植到视网膜下间隙。基于行为和电生理学研究，视网膜移植已被证明能显著改善大鼠视网膜变性模型视网膜移植后的视觉反应。移植效果可能受多种因素影响，如移植时受体的年龄和所用物种的类型。改良的功能评估技术有助于更好地理解动物模型中视力改善背后的生理机制。
