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P物质诱导的豚鼠回肠初始短暂收缩与肌醇磷脂水解之间的关系。

Relationship between substance P-induced initial transient contractions and inositol phospholipid hydrolysis in guinea pig ileum.

作者信息

Honda K, Takano Y, Yamada A, Kamiya H

机构信息

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.

出版信息

J Pharmacobiodyn. 1991 Jul;14(7):393-7. doi: 10.1248/bpb1978.14.393.

DOI:10.1248/bpb1978.14.393
PMID:1724988
Abstract

The effects of neomycin on substance P (SP)-induced inositol phospholipid hydrolysis and muscle contraction were studied in longitudinal smooth muscle of guinea pig ileum. Various tachykinin peptides including SP stimulated inositol phospholipid hydrolysis in guinea pig ileum. Neomycin (2.5 mM) reduced both the contractions and the accumulation of [3H]inositol phosphates induced by SP. These results suggest that the initial transient contractions induced by SP are coupled to inositol phospholipid hydrolysis.

摘要

在豚鼠回肠纵行平滑肌中研究了新霉素对P物质（SP）诱导的肌醇磷脂水解和肌肉收缩的影响。包括SP在内的各种速激肽肽类可刺激豚鼠回肠中的肌醇磷脂水解。新霉素（2.5 mM）可减少SP诱导的收缩以及[3H]肌醇磷酸的积累。这些结果表明，SP诱导的初始短暂收缩与肌醇磷脂水解相关联。

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