霉菌酸的催化不对称合成。
Catalytic asymmetric synthesis of mycocerosic acid.
作者信息
ter Horst Bjorn, Feringa Ben L, Minnaard Adriaan J
机构信息
Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
出版信息
Chem Commun (Camb). 2007 Feb 7(5):489-91. doi: 10.1039/b612593j. Epub 2006 Nov 6.
The first catalytic asymmetric total synthesis of mycocerosic acid was achieved via the application of iterative enantioselective 1,4-addition reactions and allows for the efficient construction of 1,3-polymethyl arrays with full stereocontrol; further exemplified by the synthesis of tetramethyl-decanoic acid, a component of the preen-gland wax of the graylag goose, Anser anser.
通过应用迭代对映选择性1,4-加成反应，首次实现了霉菌蜡酸的催化不对称全合成，该反应能够在完全立体控制下高效构建1,3-多甲基阵列；以灰雁（Anser anser）尾脂腺蜡的一种成分四甲基癸酸的合成为例进一步说明。
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