以B淋巴细胞缺失为表现的全身型幼年类风湿关节炎。

Systemic onset juvenile rheumatoid arthritis presenting with absence of B lymphocytes.

作者信息

Artac Hasibe, Alp Hayrullah, Keles Sevgi, Reisli Ismail, Tunc Recep

机构信息

Departments of Pediatrics, Pediatric Immunology and Allergy Division, Selcuk University Meram Medical Faculty, Beyşehir Yolu, 42080 Konya, Turkey.

出版信息

Rheumatol Int. 2007 Aug;27(10):981-3. doi: 10.1007/s00296-007-0316-7. Epub 2007 Jan 25.

DOI:10.1007/s00296-007-0316-7

PMID:17252261

Abstract

Juvenile rheumatoid arthritis (JRA) is a complex disease involving the interactions of several cell populations with different mediators. Herein, we report a five-year-old girl with systemic-onset JRA. At admission, peripheral blood flowcytometric analysis showed the percentages of CD19(+) and CD20(+) B cells were <1%. These values returned to normal on the tenth day of steroid treatment. This is the first report of JRA presented with absence of B lymphocytes in the literature and suggested that lymphocytes subset analysis could change with treatment in patients with JRA. Different clinical signs and symptoms reflecting aspects of JRA are critical for the etiology of the disease and to identify new strategies for treatment.

摘要

幼年类风湿性关节炎（JRA）是一种复杂的疾病，涉及多种细胞群体与不同介质之间的相互作用。在此，我们报告一名患有全身型JRA的5岁女孩。入院时，外周血流式细胞术分析显示CD19(+)和CD20(+) B细胞的百分比<1%。这些值在类固醇治疗的第10天恢复正常。这是文献中首次报道JRA患者出现B淋巴细胞缺失的情况，并提示JRA患者的淋巴细胞亚群分析可能会随治疗而改变。反映JRA各个方面的不同临床体征和症状对于该疾病的病因以及确定新的治疗策略至关重要。