Milner Eric C B, Anolik Jennifer, Cappione Amedeo, Sanz Iñaki
Department of Medicine, Clinical Immunology and Rheumatology Unit, University of Rochester Medical School, 601 Elmwood Avenue, Box 695, Rochester, NY 14642, USA.
Springer Semin Immunopathol. 2005 Mar;26(4):433-52. doi: 10.1007/s00281-004-0188-9. Epub 2005 Jan 5.
B cells play a variety of immunoregulatory roles through their antigen-presentation ability and through cytokine and chemokine production. Innate immune activation of B cells may play a beneficial role through the generation of natural cross-reactive antibodies, by maintaining B cell memory and by exercising immunomodulatory functions that may provide protection against autoimmunity. In this article, we review human B cell populations and their functional properties, with a particular focus on a population of inherently autoreactive B cells, which seem to play an important physiological role in innate immunity, but which, if selected into adaptive immune responses, appear to become pathogenic agents in systemic lupus erythematosus.
B细胞通过其抗原呈递能力以及细胞因子和趋化因子的产生发挥多种免疫调节作用。B细胞的固有免疫激活可能通过产生天然交叉反应性抗体、维持B细胞记忆以及行使可能提供针对自身免疫保护的免疫调节功能而发挥有益作用。在本文中，我们综述了人类B细胞群体及其功能特性，特别关注一类内在自身反应性B细胞群体，这类细胞似乎在固有免疫中发挥重要生理作用，但如果被选入适应性免疫反应，在系统性红斑狼疮中似乎会成为致病因子。
