某些第三代头孢菌素、其合成中间体及反应副产物的13C核磁共振光谱分析

13C NMR spectroscopy of some third-generation cephalosporins, their synthetic intermediaries and reaction byproducts.

作者信息

López Miguel A, Rodríguez Zalua, González Maritza, Tolón Blanca, Avila Rizette, Rodríguez Juan C, Vélez-Castro Hermán, Fini Adamo

机构信息

Centro de Química Farmacéutica, Avenida 200 y 21, Siboney, Playa, CP 16042, Ciudad de La Habana, Cuba.

出版信息

Magn Reson Chem. 2007 Mar;45(3):236-9. doi: 10.1002/mrc.1952.

DOI:10.1002/mrc.1952

PMID:17252617

Abstract

(13)C NMR spectroscopic data for 25 cephalosporin derivatives were assigned by combination of one- and two-dimensional experiments. The effect of the substitution at C-3, C-7 and C-4 acid group positions on the chemical shifts of the cephem nucleus is discussed.

摘要

通过一维和二维实验相结合的方法，对25种头孢菌素衍生物的(13)C核磁共振光谱数据进行了归属。讨论了C-3、C-7和C-4酸基位置上的取代基对头孢烯母核化学位移的影响。