Thomas R E, Baker P, Lorenzetti D
University of Calgary, Department of Medicine, UCMC, #1707-1632 14th Avenue, Calgary, Alberta, Canada, T2M 1N7.
Cochrane Database Syst Rev. 2007 Jan 24(1):CD004493. doi: 10.1002/14651858.CD004493.pub2.
There is evidence that children's decisions to smoke are influenced by family and friends.
To assess the effectiveness of interventions to help family members to strengthen non-smoking attitudes and promote non-smoking by children and other family members.
We searched 14 electronic bibliographic databases, including the Cochrane Tobacco Addiction Group specialized register, MEDLINE, EMBASE, PsycINFO and CINAHL. We also searched unpublished material, and the reference lists of key articles. We performed both free-text Internet searches and targeted searches of appropriate websites, and we hand-searched key journals not available electronically. We also consulted authors and experts in the field. The most recent search was performed in July 2006.
Randomized controlled trials (RCTs) of interventions with children (aged 5-12) or adolescents (aged 13-18) and family members to deter the use of tobacco. The primary outcome was the effect of the intervention on the smoking status of children who reported no use of tobacco at baseline. Included trials had to report outcomes measured at least six months from the start of the intervention.
We reviewed all potentially relevant citations and retrieved the full text to determine whether the study was an RCT and matched our inclusion criteria. Two authors independently extracted study data and assessed them for methodological quality. The studies were too limited in number and quality to undertake a formal meta-analysis, and we present a narrative synthesis.
We identified 19 RCTs of family interventions to prevent smoking. We identified five RCTs in Category 1 (minimal risk of bias on all counts); nine in Category 2 (a risk of bias in one or more areas); and five in Category 3 (risks of bias in design and execution such that reliable conclusions cannot be drawn from the study). Considering the fourteen Category 1 and 2 studies together: (1) four of the nine that tested a family intervention against a control group had significant positive effects, but one showed significant negative effects; (2) one of the five RCTs that tested a family intervention against a school intervention had significant positive effects; (3) none of the six that compared the incremental effects of a family plus a school programme to a school programme alone had significant positive effects; (4) the one RCT that tested a family tobacco intervention against a family non-tobacco safety intervention showed no effects; and (5) the one trial that used general risk reduction interventions found the group which received the parent and teen interventions had less smoking than the one that received only the teen intervention (there was no tobacco intervention but tobacco outcomes were measured). For the included trials the amount of implementer training and the fidelity of implementation are related to positive outcomes, but the number of sessions is not.
AUTHORS' CONCLUSIONS: Some well-executed RCTs show family interventions may prevent adolescent smoking, but RCTs which were less well executed had mostly neutral or negative results. There is thus a need for well-designed and executed RCTs in this area.
有证据表明儿童吸烟的决定受到家人和朋友的影响。
评估干预措施的有效性,以帮助家庭成员强化不吸烟态度,并促使儿童及其他家庭成员戒烟。
我们检索了14个电子文献数据库,包括Cochrane烟草成瘾小组专业注册库、MEDLINE、EMBASE、PsycINFO和CINAHL。我们还检索了未发表的资料以及关键文章的参考文献列表。我们进行了自由文本互联网搜索和对相关网站的定向搜索,并手工检索了无法通过电子方式获取的关键期刊。我们还咨询了该领域的作者和专家。最近一次检索于2006年7月进行。
针对5至12岁儿童或13至18岁青少年及其家庭成员开展的旨在阻止烟草使用的干预措施的随机对照试验(RCT)。主要结局是干预措施对基线时报告不吸烟的儿童吸烟状况的影响。纳入试验必须报告从干预开始至少六个月后测量的结局。
我们查阅了所有可能相关的文献,并获取全文以确定该研究是否为RCT以及是否符合我们的纳入标准。两位作者独立提取研究数据并评估其方法学质量。研究数量和质量有限,无法进行正式的荟萃分析,因此我们进行了叙述性综合分析。
我们确定了19项预防吸烟的家庭干预RCT。我们在第1类(所有方面偏倚风险最小)中确定了5项RCT;在第2类(一个或多个领域存在偏倚风险)中确定了9项;在第3类(设计和实施存在偏倚风险,以至于无法从研究中得出可靠结论)中确定了5项。综合考虑14项第1类和第2类研究:(1)9项将家庭干预与对照组进行比较的研究中,有4项产生了显著的积极效果,但有1项显示出显著的消极效果;(2)5项将家庭干预与学校干预进行比较的RCT中,有1项产生了显著的积极效果;(3)6项比较家庭加学校计划与单独学校计划的增量效果的研究中,没有一项产生显著的积极效果;(4)1项将家庭烟草干预与家庭非烟草安全干预进行比较的RCT没有显示出效果;(5)1项使用一般风险降低干预措施的试验发现,接受父母和青少年干预的组吸烟少于仅接受青少年干预的组(没有烟草干预,但测量了烟草相关结局)。对于纳入试验,实施者培训的数量和实施的保真度与积极结局相关,但课程数量无关。
一些执行良好的RCT表明家庭干预可能预防青少年吸烟,但执行较差的RCT大多产生中性或消极结果。因此,该领域需要设计良好且执行得当的RCT。