铑催化的八元环合成。

Rhodium-catalyzed synthesis of eight-membered rings.

作者信息

DeBoef Brenton, Counts W Richard, Gilbertson Scott R

机构信息

Department of Chemistry, Washington University, One Brookings Drive, Saint Louis, Missouri 63130-4899, USA.

出版信息

J Org Chem. 2007 Feb 2;72(3):799-804. doi: 10.1021/jo0620462.

DOI:10.1021/jo0620462

PMID:17253798

Abstract

Experiments to develop a rhodium catalyst for the [4 + 2 + 2] cycloisomerization of dienynes with a second alkyne are described. The generality of the reaction is probed in terms of dienyne structure and alkyne structure. A catalyst system that provides cyclooctatrienes in greater than 70% yield is reported. Several experiments to determine the nature of the catalyst are described.

摘要

描述了开发用于二烯炔与第二种炔烃进行[4 + 2 + 2]环异构化反应的铑催化剂的实验。从二烯炔结构和炔烃结构方面探究了该反应的通用性。报道了一种能以大于70%的产率提供环辛三烯的催化剂体系。还描述了几个确定催化剂性质的实验。