通过铑催化芳基醛亚胺与炔烃的氧化交叉偶联/环化反应合成异喹啉。
Isoquinoline synthesis via rhodium-catalyzed oxidative cross-coupling/cyclization of aryl aldimines and alkynes.
作者信息
Guimond Nicolas, Fagnou Keith
机构信息
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Canada K1N 6N5.
出版信息
J Am Chem Soc. 2009 Sep 2;131(34):12050-1. doi: 10.1021/ja904380q.
PMID:19705909
Abstract
A general rhodium-catalyzed oxidative coupling reaction between internal alkynes and aryl aldimines is described. This process affords 3,4-disubstituted isoquinolines in good yield and high regioselectivity. Preliminary mechanistic studies suggest that the C-N bond formation arises from the reductive elimination of a rhodium(III) species.
摘要
描述了一种铑催化的内炔烃与芳基醛亚胺之间的通用氧化偶联反应。该过程以良好的产率和高区域选择性得到3,4-二取代异喹啉。初步机理研究表明，C-N键的形成源于铑(III)物种的还原消除。
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