Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J.
作者信息
Botta Maurizio, Armaroli Silvia, Castagnolo Daniele, Fontana Gabriele, Pera Paula, Bombardelli Ezio
机构信息
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, via A. Moro, 53100 Siena, Italy.
出版信息
Bioorg Med Chem Lett. 2007 Mar 15;17(6):1579-83. doi: 10.1016/j.bmcl.2006.12.101. Epub 2007 Jan 8.
PMID:17254787
Abstract
A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0.1 microM when tested in combination with paclitaxel.
摘要
Zotero 插件