Jestin V, Cherbonnel M
CNEVA Laboratoire Central de Recherches Avicole et Porcine, Unité de Pathologie Aviaire, Ploufragan, France.
Ann Rech Vet. 1991;22(4):365-72.
Newcastle disease virus (NDV) envelope glycoproteins that are expressed at the surface of fixed NDV (Ploufragan strain)-infected chick fibroblasts induce interferon (IFN) in mouse spleen cells. HN protein appears to be involved, since an anti-HN monoclonal antibody (Mab 3115) reduces the IFN production to 6% at most. However, the precise site of the molecule responsible for IFN induction is probably not exactly superimposed on the Mab 3115-epitope, since the NDV (83309 strain)-HN protein, which exhibits a modified Mab 3115-epitope, is also able to induce IFN. These preliminary results require further investigation in order to characterize the IFN herein demonstrated, to establish whether this induction mechanism exists in chicken lymphoid cells and to more accurately define the part of the HN molecule involved.
新城疫病毒（NDV）包膜糖蛋白在固定的感染了NDV（Ploufragan株）的鸡成纤维细胞表面表达，可在小鼠脾细胞中诱导干扰素（IFN）产生。HN蛋白似乎参与其中，因为一种抗HN单克隆抗体（Mab 3115）可将IFN产生最多降低至6%。然而，负责IFN诱导的分子精确位点可能与Mab 3115表位并不完全重叠，因为具有修饰的Mab 3115表位的NDV（83309株）-HN蛋白也能够诱导IFN。这些初步结果需要进一步研究，以便对本文所证明的IFN进行特性描述，确定这种诱导机制是否存在于鸡淋巴细胞中，并更准确地界定HN分子中参与的部分。
