Szalaty H, Lobodzińska M, Albin M
Arch Immunol Ther Exp (Warsz). 1977;25(5):719-23.
The present study was undertaken to compare the production of interferon by immunized mice in response to different viral inducers. Porton mice were immunized with NDV or A/Wr11/57 virus by injecting 6-week-old animals with virus on days 1, 7, and 14. The interferon response was investigated 3 weeks later. Compared with controls, the A-immunized mice after stimulation in vivo, produced more interferon when NDV was used as inducer. It was shown in sera as well as in washings of peritoneal cells. In experiments in vitro induction of interferon with NDV or A/Wr11/57 virus in macrophages of immunized mice resulted in significant rise in interferon levels. These results are in agreement with earlier investigation of others and support the role of immune recognition in the interferon response.
本研究旨在比较免疫小鼠对不同病毒诱导剂产生干扰素的情况。通过在第1、7和14天给6周龄的Porton小鼠注射病毒，使其用新城疫病毒（NDV）或A/Wr11/57病毒免疫。3周后研究干扰素反应。与对照组相比，体内受刺激后的A免疫小鼠在使用NDV作为诱导剂时产生更多干扰素。在血清以及腹膜细胞洗液中均有显示。在体外实验中，用NDV或A/Wr11/57病毒在免疫小鼠的巨噬细胞中诱导干扰素，导致干扰素水平显著升高。这些结果与其他人早期的研究一致，并支持免疫识别在干扰素反应中的作用。
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