Cuchacovich R, Justiniano M, Espinoza L R
Division of Rheumatology, Department of Internal Medicine, LSU Health Sciences Center, 2020 Gravier Street, 7th Floor, Box E-20, New Orleans, LA 70115, USA.
Clin Rheumatol. 2007 Oct;26(10):1769-71. doi: 10.1007/s10067-006-0510-0. Epub 2007 Jan 26.
Churg-Strauss syndrome (CSS) is a rare vasculitic disorder that generally occurs in patients with bronchial asthma. CSS is being increasingly recognized in asthmatic patients treated with leukotriene receptor antagonists. However, the nature of this relationship remains to be elucidated. The present report describes three asthmatic patients who developed clinical manifestations highly suggestive of CSS, although one patient lacked the presence of eosinophilia. The patient, however, exhibited biopsy-proven cutaneous necrotizing vasculitis, which improved after withdrawal of montelukast. The second patient presented with systemic constitutional signs including fever, malaise, arthralgias, clinical jaundice, peripheral blood eosinophilia, and biopsy-proven eosinophilic hepatitis. The third patient also had circulating eosinophilia, scleritis, and arthritis. All patients improved after discontinuation of the leukotriene receptor antagonist (montelukast).
变应性肉芽肿性血管炎（CSS）是一种罕见的血管炎疾病，通常发生于支气管哮喘患者。在接受白三烯受体拮抗剂治疗的哮喘患者中，CSS越来越多地被认识到。然而，这种关系的本质仍有待阐明。本报告描述了三名哮喘患者，他们出现了高度提示CSS的临床表现，尽管其中一名患者缺乏嗜酸性粒细胞增多。然而，该患者表现出经活检证实的皮肤坏死性血管炎，停用孟鲁司特后病情改善。第二名患者出现全身症状，包括发热、不适、关节痛、临床黄疸、外周血嗜酸性粒细胞增多以及经活检证实的嗜酸性粒细胞性肝炎。第三名患者也有循环嗜酸性粒细胞增多、巩膜炎和关节炎。所有患者在停用白三烯受体拮抗剂（孟鲁司特）后病情均有改善。
