Kretschmer V, Planitz C, Dietrich G, Pflüger H H
Abt. Transfusionsmedizin und Gerinnungsphysiologie, Universitätsklinikum Marburg.
Beitr Infusionsther. 1991;28:204-8.
115 patients with bone marrow aplasia/hypoplasia received a total of 567 transfusions of fresh HLA-selected platelet concentrates at random from the AS-104 and CS-3000 and, whenever possible, from both separators using the same donor. By daily platelet counting pre and up to seven days post transfusion, the posttransfusional increments per 10(11) platelets transfused were calculated. Fresh platelets collected from the AS-104 showed comparable in vivo recovery at the first day post transfusion but significantly better survival compared to those from the CS-3000. This is in line with in vitro studies published before, where better in vitro function and morphology were observed. Increased platelet yields and improval of the platelet survival of the PC's from the AS-104 should result in prolonged transfusion intervals. When additionally evaluating a limited number of PC's from the AS-104 stored in teflon bags up to five days before transfusion (n = 12), our results were not favorable compared to PC's from the CS-3000 stored in polyolefine bags. As this seemed to be due to the geometry of the bags, this was consequently changed.
115例骨髓再生障碍/发育不全患者共接受了567次新鲜的HLA筛选血小板浓缩物输注，这些血小板浓缩物随机取自AS - 104和CS - 3000血细胞分离机，并且只要有可能，就使用相同供体从两台血细胞分离机采集。通过在输血前及输血后最多7天每日进行血小板计数，计算每输注10(11)个血小板后的输血后增加值。与来自CS - 3000的血小板相比，从AS - 104采集的新鲜血小板在输血后第一天显示出相当的体内回收率，但生存期明显更长。这与之前发表的体外研究结果一致，在那些研究中观察到了更好的体外功能和形态。来自AS - 104的血小板产量增加以及血小板生存期改善应会导致输血间隔延长。另外，当评估在输血前最多5天储存在聚四氟乙烯袋中的有限数量的AS - 104血小板浓缩物(n = 12)时，与储存在聚烯烃袋中的CS - 3000血小板浓缩物相比，我们的结果并不理想。由于这似乎是由于袋子的形状所致，因此对袋子进行了更换。
