孕期及产褥期母亲吸烟、肥胖与静脉血栓栓塞风险：一项基于人群的巢式病例对照研究。

Maternal smoking, obesity, and risk of venous thromboembolism during pregnancy and the puerperium: a population-based nested case-control study.

作者信息

Larsen Torben Bjerregaard, Sørensen Henrik Toft, Gislum Mette, Johnsen Søren Paaske

机构信息

Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Denmark.

出版信息

Thromb Res. 2007;120(4):505-9. doi: 10.1016/j.thromres.2006.12.003. Epub 2007 Jan 25.

DOI:10.1016/j.thromres.2006.12.003

PMID:17257657

Abstract

BACKGROUND

Smoking and obesity are associated with adverse pregnancy outcomes. The aim of the present study was to examine the association between smoking, obesity (BMI>30), and risk for venous thromboembolism (VTE) during pregnancy and the puerperium.

MATERIALS AND METHODS

In a population-based case-control study nested within a Danish cohort of 71,729 women, we identified 129 cases with VTE in pregnancy or the puerperium, and 258 pregnant non-VTE controls. We obtained data from medical records regarding current smoking status, BMI, and other covariates, and computed the odds ratios (OR) for VTE as a measure of relative risk.

RESULTS

Smoking and obesity were associated with increased risk of VTE during pregnancy and the puerperium (adjusted OR 2.7 (95% CI: 1.5, 4.9) and 5.3 (95% CI: 2.1, 13.5), respectively). Obesity appeared to be associated with a higher risk of pulmonary embolism (adjusted OR: 14.9 (95% CI: 3.0, 74.8) than of deep venous thrombosis (adjusted OR: 4.4, 95% CI: 1.6, 11.9).

CONCLUSION

Smoking and obesity are risk factors for VTE in pregnancy and the puerperium.

摘要

背景

吸烟和肥胖与不良妊娠结局相关。本研究的目的是探讨吸烟、肥胖（BMI>30）与妊娠及产褥期静脉血栓栓塞症（VTE）风险之间的关联。

材料与方法

在一项基于丹麦71729名女性队列的人群病例对照研究中，我们确定了129例妊娠或产褥期发生VTE的病例，以及258名未发生VTE的妊娠对照。我们从医疗记录中获取了有关当前吸烟状况、BMI及其他协变量的数据，并计算VTE的比值比（OR）作为相对风险的衡量指标。

结果

吸烟和肥胖与妊娠及产褥期VTE风险增加相关（调整后的OR分别为2.7（95%CI：1.5，4.9）和5.3（95%CI：2.1，13.5））。肥胖似乎与肺栓塞风险较高相关（调整后的OR：14.9（95%CI：3.0，74.8）），高于深静脉血栓形成（调整后的OR：4.4，95%CI：1.6，11.9）。