Morimoto T, Hanamura T, Sasaki T, Saito I, Takakura K
Department of Neurosurgery, Faculty of Medicine, University of Tokyo, Japan.
Neurol Med Chir (Tokyo). 1991 Oct;31(10):635-40. doi: 10.2176/nmc.31.635.
The effect of endothelin-1 on regional cerebral blood flow (rCBF) was investigated in adult mongrel cats. Endothelin-1 was injected into the cisterna magna and rCBF was measured by the hydrogen clearance method before and every 30 minutes for 180 minutes after the injection. Endothelin-1 (10(-11) mol and 10(-9) mol) induced a significant decrease in rCBF and an increase in arterial pressure. The effects of endothelin-1 on rCBF and arterial pressure were mediated, at least in part, by Ca2+, because pretreatment with intracisternally injected nicardipine prevented the changes. Cerebral angiograms obtained before and after endothelin-1 injection demonstrated severe constriction of the basilar artery, but constriction of the internal carotid and middle cerebral arteries was mild. Since the rCBF measured was in the territory of the middle cerebral artery, the decrease in blood flow was probably not solely due to the artery constriction. Other mechanisms such as arteriole constriction and/or regulation of rCBF by the central nervous system may also occur.
在成年杂种猫中研究了内皮素 -1 对局部脑血流量（rCBF）的影响。将内皮素 -1 注入小脑延髓池，并在注射前以及注射后每 30 分钟用氢清除法测量 rCBF，共测量 180 分钟。内皮素 -1（10⁻¹¹ 摩尔和 10⁻⁹ 摩尔）可引起 rCBF 显著降低和动脉压升高。内皮素 -1 对 rCBF 和动脉压的影响至少部分是由 Ca²⁺ 介导的，因为脑池内注射尼卡地平预处理可防止这些变化。内皮素 -1 注射前后获得的脑血管造影显示基底动脉严重收缩，但颈内动脉和大脑中动脉收缩较轻。由于所测量的 rCBF 是在大脑中动脉供血区域，血流量的减少可能并非仅仅由于动脉收缩。其他机制如小动脉收缩和/或中枢神经系统对 rCBF 的调节也可能发生。
