Messier P E, Auclair C
J Embryol Exp Morphol. 1975 Oct;34(2):339-54.
Neurulation and interkinetic nuclear migration was studied in cells of the forming neural tube of chick embryos submitted to a variety of treatments. Our results show that cytochalasin B (5 mug/ml) does not protect microtubules against disruption occurring after 3 h at 2 degrees C nor does it prevent their repolymerization once they are cold-disrupted. However, db-cAMP protects microtubules against such cold disruption. We indicate that the inhibitory effect of cytochalasin B on interkinetic nuclear migration cannot be ascribed to an effect on microtubules.
在接受各种处理的鸡胚形成神经管的细胞中研究了神经胚形成和核内有丝分裂期核迁移。我们的结果表明，细胞松弛素B（5微克/毫升）不能保护微管免受在2℃下3小时后发生的破坏，也不能阻止它们在冷破坏后重新聚合。然而，二丁酰环磷腺苷（db-cAMP）能保护微管免受这种冷破坏。我们指出，细胞松弛素B对核内有丝分裂期核迁移的抑制作用不能归因于对微管的影响。
