Attridge S
Department of Microbiology & Immunology, University of Adelaide, South Australia.
Vaccine. 1991 Dec;9(12):877-82. doi: 10.1016/0264-410x(91)90007-s.
Previous studies have shown that oral immunization with Salmonella typhi Ty21a-based clones expressing Vibrio cholerae O-antigen elicits serum antibody responses against the foreign polysaccharide in human volunteers. These responses are conveniently assayed by complement-dependent bacteriolysis of V. cholerae. In this report the bactericidal responses generated by two such clones are analysed in relation to the pre-immunization titres of various serum antibodies. A significant association was found, in that recipients with higher prevaccine titres of anti-V. cholerae bactericidal antibodies were less likely to register significant bactericidal responses following immunization. These results are discussed in relation to the concept of vaccine exclusion.
先前的研究表明，用表达霍乱弧菌O抗原的伤寒沙门氏菌Ty21a克隆进行口服免疫可在人类志愿者中引发针对外源多糖的血清抗体反应。这些反应可通过霍乱弧菌的补体依赖性细菌溶解方便地进行检测。在本报告中，分析了两个这样的克隆产生的杀菌反应与各种血清抗体的免疫前滴度的关系。发现了一种显著的关联，即免疫前抗霍乱弧菌杀菌抗体滴度较高的接受者在免疫后产生显著杀菌反应的可能性较小。结合疫苗排除的概念对这些结果进行了讨论。
