Bosser Gilles, Gauchard Gérome C, Brembilla-Perrot Béatrice, Marçon François, Perrin Philippe P
Service de Cardiologie Pédiatrique, Hôpital d'Enfants, Centre Hospitalier Universitaire de Nancy, Vandoeuvre-lès-Nancy, France.
Brain Res Bull. 2007 Mar 15;71(5):485-92. doi: 10.1016/j.brainresbull.2006.10.013. Epub 2006 Nov 13.
In children, vasovagal syncope (VVS) is the most common cause of syncope and motion sickness (MS) is also very frequent, with many symptoms of an autonomic nature. To study a possible relationship between VVS susceptibility and MS susceptibility in young patients, 21 children (10 boys, 11.3+/-2.6 years) with recurrent syncope or presyncope were explored with a questionnaire concerning their vasovagal symptoms, susceptibility to MS and familial history. A tilt-table test and a dynamic posturography with Equitest (Sensory Organisation Test (SOT), in six conditions) were performed. Children were divided into two groups: A with a positive tilt-table test and particular susceptibility to VVS (n=13/21, six boys) and B with negative tilt-table test. A control group of 30 healthy children (15 boys, 11.4+/-2.4 years) was studied for MS susceptibility and familial history. VVS susceptibility was related to MS susceptibility (MS susceptibility was 69.3% in Group A versus 12.5% in Group B (p=0.0237) and 16.7% in control group (p=0.0028)) and also to SOT scores which are related both to the role of vestibule in equilibrium and to MS susceptibility, with lower values in Group A than Group B (condition 5: 47.9+/-12.3% versus 66.0+/-13.8%, p=0.0189 and vestibular (ratio of conditions 5/1): 51.8+/-12.7% versus 71.3+/-13.5%, p=0.0147). Our study demonstrates, for the first time, a relationship between VVS susceptibility and MS susceptibility in a population of children with a particular susceptibility to VVS. This paradigm may prove useful in better understanding the mechanisms underlying the susceptibility to VVS and MS.
在儿童中，血管迷走性晕厥（VVS）是晕厥最常见的原因，晕动病（MS）也很常见，有许多自主神经性质的症状。为了研究年轻患者中VVS易感性和MS易感性之间的可能关系，我们用一份关于血管迷走症状、MS易感性和家族史的问卷对21名患有复发性晕厥或晕厥前期的儿童（10名男孩，年龄11.3±2.6岁）进行了调查。进行了倾斜试验和使用Equitest的动态姿势描记法（感觉组织试验（SOT），六种情况）。儿童被分为两组：A组倾斜试验阳性且对VVS有特殊易感性（n = 13/21，6名男孩），B组倾斜试验阴性。对30名健康儿童（15名男孩，年龄11.4±2.4岁）的对照组进行了MS易感性和家族史研究。VVS易感性与MS易感性相关（A组MS易感性为69.3%，B组为12.5%（p = 0.0237），对照组为16.7%（p = 0.0028）），也与SOT评分相关，SOT评分既与前庭在平衡中的作用有关，也与MS易感性有关，A组的值低于B组（情况5：47.9±12.3%对66.0±13.8%，p = 0.0189；前庭（情况5/1的比值）：51.8±12.7%对71.3±13.5%，p = 0.0147）。我们的研究首次证明了在对VVS有特殊易感性的儿童群体中，VVS易感性与MS易感性之间的关系。这种模式可能有助于更好地理解VVS和MS易感性的潜在机制。
