Yang Liu, Lu Jian-wei, An Jing, Jiang Xuan
Department of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. yangliutcm@ 21cn.com
Nan Fang Yi Ke Da Xue Xue Bao. 2006 Dec;26(12):1777-9.
To observe the effect of Tribulus terrestris extract on melanocyte stimulating hormone (MSH) expression in C57BL/6J mouse hair follicles, and investigate the role of Tribulus terrestris extract in activation, proliferation, epidermal migration of dormant hair follicle melanocytes.
The aqueous extract of Tribulus terrestris was administered orally in specific pathogen-free C57BL/6J mouse at the daily dose equivalent to 1 g/1 kg in adult human, and the expression and distribution of MSH in the mouse hair follicles was observed with immunohistochemistry.
The positivity rate of MSH expression in the hair follicle melanocytes was 75% in mice treated with the extract, significantly higher than the rate of only 18.75% in the control group (P<0.01).
The aqueous extract of Tribulus terrestris can significantly increase MSH expression in the hair follicle melanocytes by activating tyrosinase activity and promoting melanocyte proliferation, melanine synthesis, and epidermal migration of dormant melanocytes.
观察刺蒺藜提取物对C57BL/6J小鼠毛囊中促黑素（MSH）表达的影响，探讨刺蒺藜提取物在激活、增殖及促进静止期毛囊黑素细胞向表皮迁移方面的作用。
将刺蒺藜水提取物以相当于成人1 g/1 kg的日剂量口服给予无特定病原体的C57BL/6J小鼠，采用免疫组化法观察小鼠毛囊中MSH的表达及分布。
提取物处理组小鼠毛囊黑素细胞中MSH表达阳性率为75%，显著高于对照组仅18.75%的阳性率（P<0.01）。
刺蒺藜水提取物可通过激活酪氨酸酶活性、促进黑素细胞增殖、黑素合成及静止期黑素细胞向表皮迁移，显著增加毛囊黑素细胞中MSH的表达。
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