Kissling R O, Bloesch A C, Sager M, Dambacher M A, Schreiber A
Clinique orthopédique universitaire Balgrist, Zurich, Suisse.
Rev Chir Orthop Reparatrice Appar Mot. 1991;77(8):562-7.
In patients suffering from, or with a history of, reflex sympathetic dystrophy (RSD), there is always a risk of exacerbation or reactivation of this disease after surgery or trauma. The use of calcitonin in the treatment of this type of disorder is well established. Starting in 1984, 18 patients with clinical symptoms of RSD or a history of this disease were given daily prophylactic treatment with salmon calcitonin (100 IU subcutaneously or as a spray). Ten of the patients underwent orthopaedic surgery and 8 received conservative treatment following trauma. The mean duration of prophylactic treatment was 4 days before and 23 days after surgery or trauma. Only one recurrence was observed (3 per cent). For comparison, a retrospective analysis of a group with the same inclusion criteria who underwent surgery or received conservative treatment after trauma, without prophylactic administration of calcitonin showed a recurrence of the underlying disease 28 per cent of the cases. It is therefore possible to recommend prophylactic administration of calcitonin, to patients with a history of RSD who are about to undergo orthopaedic surgery or conservative treatment following trauma.
对于患有反射性交感神经营养不良（RSD）或有该病病史的患者，术后或创伤后始终存在该病加重或复发的风险。降钙素用于治疗此类病症已得到充分证实。从1984年开始，对18例有RSD临床症状或该病病史的患者给予鲑鱼降钙素每日预防性治疗（100 IU皮下注射或喷雾给药）。其中10例患者接受了骨科手术，8例在创伤后接受了保守治疗。预防性治疗的平均持续时间为手术或创伤前4天和术后23天。仅观察到1例复发（3%）。作为对照，对一组具有相同纳入标准、在未预防性给予降钙素的情况下接受手术或创伤后保守治疗的患者进行回顾性分析，发现基础疾病的复发率为28%。因此，对于即将接受骨科手术或创伤后保守治疗且有RSD病史的患者，推荐预防性给予降钙素。
