金黄色葡萄球菌临床胸腺嘧啶依赖性小菌落变体在稳定期后存活率的提高源于缺乏功能性三羧酸循环。
Enhanced post-stationary-phase survival of a clinical thymidine-dependent small-colony variant of Staphylococcus aureus results from lack of a functional tricarboxylic acid cycle.
作者信息
Chatterjee Indranil, Herrmann Mathias, Proctor Richard A, Peters Georg, Kahl Barbara C
机构信息
Institute of Medical Microbiology and Hygiene, University of Saarland, Kirrberger Str., Building 43, Homburg/Saar 66421, Germany.
出版信息
J Bacteriol. 2007 Apr;189(7):2936-40. doi: 10.1128/JB.01444-06. Epub 2007 Jan 26.
Abstract
The mechanisms underlying the persistence of the Staphylococcus aureus small-colony variant (SCV) are not fully elucidated. In this study, clinical thymidine-dependent SCVs displayed altered expression of citB, clpC, and arcA genes, reduced acetate catabolization, and enhanced survival. These results implicate the importance of changes in tricarboxylic acid cycle and acetic acid metabolism in SCV survival and persistence.
摘要
金黄色葡萄球菌小菌落变异株（SCV）持续存在的潜在机制尚未完全阐明。在本研究中，临床胸腺嘧啶核苷依赖性SCV显示citB、clpC和arcA基因表达改变，乙酸分解代谢减少，存活率提高。这些结果表明三羧酸循环和乙酸代谢变化在SCV存活和持续存在中的重要性。
相似文献
1
Enhanced post-stationary-phase survival of a clinical thymidine-dependent small-colony variant of Staphylococcus aureus results from lack of a functional tricarboxylic acid cycle.
J Bacteriol. 2007 Apr;189(7):2936-40. doi: 10.1128/JB.01444-06. Epub 2007 Jan 26.
2
Staphylococcus aureus ClpC is required for stress resistance, aconitase activity, growth recovery, and death.
J Bacteriol. 2005 Jul;187(13):4488-96. doi: 10.1128/JB.187.13.4488-4496.2005.
3
Small colony variants of Staphylococcus aureus reveal distinct protein profiles.
Proteomics. 2011 Jun;11(12):2476-90. doi: 10.1002/pmic.201000796. Epub 2011 May 18.
4
Staphylococcus aureus small colony variants show common metabolic features in central metabolism irrespective of the underlying auxotrophism.
Front Cell Infect Microbiol. 2014 Oct 21;4:141. doi: 10.3389/fcimb.2014.00141. eCollection 2014.
5
Catabolite control protein E (CcpE) is a LysR-type transcriptional regulator of tricarboxylic acid cycle activity in Staphylococcus aureus.
J Biol Chem. 2013 Dec 13;288(50):36116-28. doi: 10.1074/jbc.M113.516302. Epub 2013 Nov 5.
6
In vivo mutations of thymidylate synthase (encoded by thyA) are responsible for thymidine dependency in clinical small-colony variants of Staphylococcus aureus.
J Bacteriol. 2008 Feb;190(3):834-42. doi: 10.1128/JB.00912-07. Epub 2007 Sep 28.
7
Staphylococcus aureus ClpC is involved in protection of carbon-metabolizing enzymes from carbonylation during stationary growth phase.
Int J Med Microbiol. 2011 Apr;301(4):341-6. doi: 10.1016/j.ijmm.2010.10.002. Epub 2011 Jan 26.
8
Molecular analysis of the thymidine-auxotrophic small colony variant phenotype of Staphylococcus aureus.
Int J Med Microbiol. 2007 Jul;297(4):217-25. doi: 10.1016/j.ijmm.2007.02.003. Epub 2007 Apr 6.
9
Emergence of Thymidine-Dependent Staphylococcus aureus Small-Colony Variants in Cystic Fibrosis Patients in Southern Brazil.
Microbiol Spectr. 2021 Sep 3;9(1):e0061421. doi: 10.1128/Spectrum.00614-21. Epub 2021 Jul 28.
10
Small colony variants (SCVs) of Staphylococcus aureus--a bacterial survival strategy.
Infect Genet Evol. 2014 Jan;21:515-22. doi: 10.1016/j.meegid.2013.05.016. Epub 2013 May 27.
引用本文的文献
1
New Metallophthalocyanines Bearing 2-Methylimidazole Moieties-Potential Photosensitizers against .
Int J Mol Sci. 2022 May 25;23(11):5910. doi: 10.3390/ijms23115910.
2
The road to success of coagulase-negative staphylococci: clinical significance of small colony variants and their pathogenic role in persistent infections.
Eur J Clin Microbiol Infect Dis. 2021 Nov;40(11):2249-2270. doi: 10.1007/s10096-021-04315-1. Epub 2021 Jul 23.
3
Engineering of the CHAPk Staphylococcal Phage Endolysin to Enhance Antibacterial Activity against Stationary-Phase Cells.
Antibiotics (Basel). 2021 Jun 16;10(6):722. doi: 10.3390/antibiotics10060722.
4
Vibrational Spectroscopy as a Sensitive Probe for the Chemistry of Intra-Phase Bacterial Growth.
Sensors (Basel). 2020 Jun 18;20(12):3452. doi: 10.3390/s20123452.
5
Persistence of : Multiple Metabolic Pathways Impact the Expression of Virulence Factors in Small-Colony Variants (SCVs).
Front Microbiol. 2020 May 21;11:1028. doi: 10.3389/fmicb.2020.01028. eCollection 2020.
6
ClpC affects the intracellular survival capacity of Staphylococcus aureus in non-professional phagocytic cells.
Sci Rep. 2019 Nov 7;9(1):16267. doi: 10.1038/s41598-019-52731-3.
7
Respiration and Small Colony Variants of .
Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.GPP3-0069-2019.
8
The Energy-Coupling Factor Transporter Module EcfAA'T, a Novel Candidate for the Genetic Basis of Fatty Acid-Auxotrophic Small-Colony Variants of .
Front Microbiol. 2018 Aug 14;9:1863. doi: 10.3389/fmicb.2018.01863. eCollection 2018.
9
Exposure of Methicillin-Resistant Staphylococcus aureus to Low Levels of the Antibacterial THAM-3ΦG Generates a Small Colony Drug-Resistant Phenotype.
Sci Rep. 2018 Jun 29;8(1):9850. doi: 10.1038/s41598-018-28283-3.
10
Reduced Innate Immune Response to a Small Colony Variant Compared to Its Wild-Type Parent Strain.
Front Cell Infect Microbiol. 2016 Dec 26;6:187. doi: 10.3389/fcimb.2016.00187. eCollection 2016.
本文引用的文献
1
Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections.
Nat Rev Microbiol. 2006 Apr;4(4):295-305. doi: 10.1038/nrmicro1384.
2
Phenotype microarray profiling of Staphylococcus aureus menD and hemB mutants with the small-colony-variant phenotype.
J Bacteriol. 2006 Jan;188(2):687-93. doi: 10.1128/JB.188.2.687-693.2006.
3
Transcription of virulence factors in Staphylococcus aureus small-colony variants isolated from cystic fibrosis patients is influenced by SigB.
J Bacteriol. 2006 Jan;188(1):64-76. doi: 10.1128/JB.188.1.64-76.2006.
4
sigmaB activity in a Staphylococcus aureus hemB mutant.
J Bacteriol. 2005 Nov;187(21):7397-406. doi: 10.1128/JB.187.21.7397-7406.2005.
5
Thymidine-dependent Staphylococcus aureus small-colony variants are associated with extensive alterations in regulator and virulence gene expression profiles.
Infect Immun. 2005 Jul;73(7):4119-26. doi: 10.1128/IAI.73.7.4119-4126.2005.
6
Staphylococcus aureus ClpC is required for stress resistance, aconitase activity, growth recovery, and death.
J Bacteriol. 2005 Jul;187(13):4488-96. doi: 10.1128/JB.187.13.4488-4496.2005.
7
Differential gene expression profiling of Staphylococcus aureus cultivated under biofilm and planktonic conditions.
Appl Environ Microbiol. 2005 May;71(5):2663-76. doi: 10.1128/AEM.71.5.2663-2676.2005.
8
Global gene expression in Staphylococcus aureus biofilms.
J Bacteriol. 2004 Jul;186(14):4665-84. doi: 10.1128/JB.186.14.4665-4684.2004.
9
Physiological characterization of a heme-deficient mutant of Staphylococcus aureus by a proteomic approach.
J Bacteriol. 2003 Dec;185(23):6928-37. doi: 10.1128/JB.185.23.6928-6937.2003.
10
Small colony variants of Staphylococcus aureus and pacemaker-related infection.
Emerg Infect Dis. 2003 Oct;9(10):1316-8. doi: 10.3201/eid0910.0302000.
Zotero 插件