Job Agnès, Raynal Marc, Kossowski Michel
Centre de Recherches du Service de Santé des Armées, La Tronche, France.
Audiol Neurootol. 2007;12(3):137-44. doi: 10.1159/000099025. Epub 2007 Jan 25.
We investigated potential markers of susceptibility to tinnitus in a group of normal hearing young pilots aged 25-35 years and with 8 +/- 5 years of aircraft noise exposure. 316 pilots were interviewed about their tinnitus status and were tested for hearing thresholds (audiograms) and distortion products otoacoustic emissions (DPOAE-grams). There was no subject with permanent tinnitus. 23% reported having occasionally perceived tinnitus after flight missions and 77% reported never having experienced tinnitus after flight missions. General discomfort in the ears to noise was higher in the occasional tinnitus group (15 vs. 6%). The major finding was that difference of susceptibility to tinnitus in normal hearing subjects exposed to noise on a daily basis seemed to be clearly related to lower DPOAEs, bilaterally, in the 1500- to 2800-kHz range. However, no difference could be observed between groups on audiograms at the 2-kHz frequency range. This study provided evidence of outer hair cell dysfunctions in normal hearing subjects exposed to noise and susceptible to tinnitus. Hypersensitivity to noise and decreased DPOAEs in a non-noise-specific frequency range support the idea of another alteration mechanism than noise itself. This point was discussed in the light of recent publications.
我们对一组年龄在25至35岁之间、有8±5年飞机噪声暴露史的听力正常的年轻飞行员进行了耳鸣易感性潜在标志物的研究。316名飞行员接受了耳鸣状况访谈,并进行了听力阈值(听力图)和畸变产物耳声发射(DPOAE图)测试。没有受试者患有永久性耳鸣。23%的人报告在飞行任务后偶尔感觉到耳鸣,77%的人报告在飞行任务后从未经历过耳鸣。偶尔出现耳鸣的组中,耳朵对噪声的总体不适感更高(15%对6%)。主要发现是,每天暴露于噪声中的听力正常受试者对耳鸣易感性的差异似乎明显与1500至2800kHz范围内双侧较低的DPOAE有关。然而,在2kHz频率范围内,两组听力图之间未观察到差异。这项研究为暴露于噪声且易患耳鸣的听力正常受试者的外毛细胞功能障碍提供了证据。在非噪声特定频率范围内对噪声的超敏反应和DPOAE降低支持了一种不同于噪声本身的改变机制的观点。根据最近的出版物对这一点进行了讨论。